Berkowitz R J, Jones P
Arch Oral Biol. 1985;30(4):377-9. doi: 10.1016/0003-9969(85)90014-7.
The production of bacteriocins by 314 Streptococcus mutans isolates from 20 mother-infant pairs was studied to test the likelihood of maternal transmission of this species. The patterns of inhibition were sufficiently different to allow differentiation of the 314 isolates into 41 bacteriocin types. The bacteriocin codes of isolates within one pair did not correspond to the codes of strains isolated from any other pair. The number of infant strains (per infant isolates) matching maternal strains within each mother-infant pair were 10/10, 10/10, 10/10, 12/12, 2/3, 10/10, 10/10, 10/10, 3/3, 5/10, 8/8, 3/3, 8/8, 3/3, 7/7, 4/4, 3/3, 8/8, 3/3 and 4/4 for pairs 1-20, respectively. Statistical analysis, utilizing a randomization test, generated a p value less than 0.0001, which is 12 standard errors above the level expected if the pairings were random.
对来自20对母婴的314株变形链球菌菌株产生细菌素的情况进行了研究，以测试该菌种母婴传播的可能性。抑制模式差异足够大，可将314株菌株分为41种细菌素类型。一对菌株中的细菌素编码与从任何其他对中分离出的菌株编码不对应。每对母婴中与母体菌株匹配的婴儿菌株数量（每例婴儿分离株），对于第1 - 20对分别为10/10、10/10、10/10、12/12、2/3、10/10、10/10、10/10、3/3、5/10、8/8、3/3、8/8、3/3、7/7、4/4、3/3、8/8、3/3和4/4。使用随机化检验的统计分析得出p值小于0.0001，这比配对为随机时预期的水平高出12个标准误差。
