Hu Chaolei, Severin Kay
Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.
Angew Chem Int Ed Engl. 2024 Jun 3;63(23):e202403834. doi: 10.1002/anie.202403834. Epub 2024 Apr 30.
A dinuclear metal-organic cage with four acrylate side chains was prepared by self-assembly. Precipitation polymerization of the cage with N-isopropylacrylamide yielded a thermoresponsive nanogel. The host properties of the cage were retained within the gel matrix, endowing the nanogel with the capability to serve as a sorbent for chloride ions in water. Moreover, a heteroleptic cage with the drug abiraterone as co-ligand was integrated into a nanogel. The addition of chloride ions induced a structural rearrangement of the metal-ligand assembly, resulting in the gradual release of abiraterone.
通过自组装制备了一种带有四个丙烯酸酯侧链的双核金属有机笼。该笼与N-异丙基丙烯酰胺进行沉淀聚合反应，得到了一种热响应性纳米凝胶。笼的主体性质保留在凝胶基质中，使纳米凝胶具有作为水中氯离子吸附剂的能力。此外，一种以药物阿比特龙作为共配体的杂配笼被整合到纳米凝胶中。氯离子的加入导致金属-配体组装体发生结构重排，从而使阿比特龙逐渐释放。
