Thoa Nguyen Thi, Son Ninh The
Faculty of Chemical Technology, Hanoi University of Industry, 298 Cau Dien, Bac Tu Liem, Hanoi, Viet Nam.
Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam.
J Pharm Pharmacol. 2025 Mar 4;77(3):352-370. doi: 10.1093/jpp/rgae039.
To get a better understanding of the scientific values of flavone scutellarein (SCT), and to encourage its applications in human health, the current review systematically summarizes the natural observation, biosynthesis, synthesis, pharmacology, pharmacokinetics, and recent synthetic advances.
Scientific sources to search for references included Google Scholar, Scopus, Web of Science, PubMed, Sci-Finder, and journal websites. The references have been collected from the 1970s to the present. "Scutellarein" is the most meaningful keyword to search for publications, in which it was used alone or in combination with other keywords.
S: SCT as a hydrophobic flavonoid can be found in various medicinal plants of the families Lamiaceae, Compositae, and Verbenaceae. Flavone SCT has drawn much interest due to its wide pharmacological effects, such as anticancer, anti-inflammation, antioxidant, antiobesity, and vasorelaxant. The SCT treatments also possessed a lot of positive results in the neuron, liver, heart, lung, kidney, bone, and skin protective experiments, and human sperm function enhancement. Its underlying mechanism of action may relate to the apoptotic program and cytokine inhibition by regulating a panel of the signaling pathway, e.g., NF-κB (nuclear factor kappa B)/MAPK (mitogen-activated protein kinase), IκBa (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitors alpha)/NF-κB, TRAF2 (tumor necrosis factor receptor-associated factor 2)/NF-κB, and PTEN (phosphatase and tension homologue deleted on chromosome 10)/Akt (protein kinase B)/NF-κB. In addition, the metabolic actions and synthetic derivative promotions of SCT were mostly based on the substitution of hydroxyl groups. Collectively, the studies that aim to highlight the role of scutellarein in preclinical and clinical treatments are urgently needed. More and more experiments to improve its bioavailability are expected.
为了更好地理解黄酮类化合物黄芩素（SCT）的科学价值，并促进其在人类健康中的应用，本综述系统地总结了自然观察、生物合成、合成方法、药理学、药代动力学以及近期的合成进展。
搜索参考文献的科学来源包括谷歌学术、Scopus、科学网、PubMed、Sci-Finder和期刊网站。参考文献收集时间从20世纪70年代至今。“黄芩素”是搜索出版物最有意义的关键词，它可单独使用或与其他关键词组合使用。
SCT作为一种疏水性黄酮类化合物，存在于唇形科、菊科和马鞭草科的多种药用植物中。黄酮类SCT因其广泛的药理作用，如抗癌、抗炎、抗氧化、抗肥胖和血管舒张作用而备受关注。SCT治疗在神经元、肝脏、心脏、肺、肾脏、骨骼和皮肤保护实验以及增强人类精子功能方面也取得了许多积极成果。其潜在作用机制可能与通过调节一系列信号通路（如NF-κB（核因子κB）/MAPK（丝裂原活化蛋白激酶）、IκBa（B细胞中κ轻链多肽基因增强子的核因子抑制剂α）/NF-κB、TRAF2（肿瘤坏死因子受体相关因子2）/NF-κB和PTEN（第10号染色体缺失的磷酸酶和张力同源物）/Akt（蛋白激酶B）/NF-κB）来抑制凋亡程序和细胞因子有关。此外，SCT的代谢作用和合成衍生物的促进作用大多基于羟基的取代。总体而言，迫切需要开展旨在突出黄芩素在临床前和临床治疗中作用的研究。预计会有越来越多提高其生物利用度的实验。
