Faculty of Chemical Technology, Hanoi University of Industry, 298 Cau Dien, Bac Tu Liem, Hanoi, Viet Nam.
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Department of Chemistry, Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam.
Fitoterapia. 2024 Dec;179:106270. doi: 10.1016/j.fitote.2024.106270. Epub 2024 Oct 21.
Peucedanum japonicum (the family Umbelliferae) is a perennial herbaceous plant with various crucial traditional values for coughs, colds, headaches, and inflammatory responses. For drug developments, the current research aims to offer an overview of the previous results in the three main aspects of traditional use, phytochemistry, pharmacological values, and molecular mechanisms regarding this medicinal species. By chromatographic analysis and separation, more than 120 isolated compounds have been obtained. Khellactone-type coumarins and phenolic compounds are the primary phytochemical classes with some coumarins, such as calipteryxin, praerutorin A, and pteryxin, being the main metabolites. Pharmacological activities of P. japonicum constituents included anticancer, antioxidative, antimicrobial, antiviral, antiplatelet, and tyrosine inhibitory activities, especially anti-inflammation and anti-obesity. It is worth mentioning that the obtained constituents joined to protect the neurons, bone, and urine systems, and exerted vasorelaxant. In general, the underlying mechanism of anti-inflammatory action can be explained by mitogen-activated protein kinase/nuclear factor-kappa B (MAPK/NF-κB) signaling pathway, whereas anti-obesity activity is deduced from regulating lipid metabolism-related genes. It also noted that pteryxin is the most active compound, but the clinical studies and synthesis of new derivatives containing enhanced medicinal values have been still limited, which should be improved.
独活（伞形科）是一种多年生草本植物，具有多种重要的传统价值，可用于咳嗽、感冒、头痛和炎症反应。在药物开发方面，目前的研究旨在概述该药用植物在传统用途、植物化学、药理作用和分子机制三个主要方面的先前研究结果。通过色谱分析和分离，已经获得了超过 120 种分离化合物。香豆酮型香豆素和酚类化合物是主要的植物化学类，一些香豆素，如 calipteryxin、praerutorin A 和 pteryxin，是主要的代谢产物。独活成分的药理活性包括抗癌、抗氧化、抗菌、抗病毒、抗血小板和酪氨酸抑制活性，特别是抗炎和抗肥胖作用。值得一提的是，所获得的成分有助于保护神经元、骨骼和泌尿系统，并具有血管舒张作用。一般来说，抗炎作用的潜在机制可以用丝裂原激活蛋白激酶/核因子-κB（MAPK/NF-κB）信号通路来解释，而抗肥胖活性则可以从调节与脂质代谢相关的基因来推断。还需要注意的是，pteryxin 是最活跃的化合物，但临床研究和含有增强药用价值的新衍生物的合成仍然有限，这方面需要进一步改进。
