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淋病中的抗菌药物耐药性

Antimicrobial Resistance in Gonorrhea.

作者信息

Vitiello Antonio, Ferrara Francesco, Boccellino Mariarosaria, Ponzo Annarita, Sabbatucci Michela, Zovi Andrea

机构信息

Ministry of Health, Rome, Italy.

Pharmaceutical Department, Asl Napoli 3 Sud, Naples, Italy.

出版信息

Microb Drug Resist. 2024 Jul;30(7):297-303. doi: 10.1089/mdr.2023.0259. Epub 2024 Apr 5.

Abstract

Antimicrobial resistance is a global public health emergency. The World Health Organization recently highlighted the growing number of new sexually transmitted infections such as gonorrhea, syphilis, and Chlamydia, which are resistant to common antibiotics. The phenomenon is also on the rise due to increasing intercontinental travel. Emerging antibiotic-resistant strains of gonorrhea are particularly associated with international spread from Southeast Asian travelers. Infection with can cause a wide spectrum of associated diseases such as dermatitis, arthritis and septic arthritis, and pelvic inflammatory disease, and can even lead to serious health consequences for the individual. Natural infection confers no immunity, and vaccination is not available currently, although in several countries, it has been reported that the antimeningococcal vaccine may protect against gonorrhea. Implementing all necessary preventive measures is crucial, as well as appropriate and timely diagnostic methods and effective antimicrobial therapeutic treatments in the correct modalities to avoid the increase of forms of gonorrhea that are resistant to common antibiotics and difficult to eradicate.

摘要

抗菌药物耐药性是全球公共卫生紧急事件。世界卫生组织最近强调,淋病、梅毒和衣原体等对常见抗生素耐药的性传播感染新病例数量不断增加。由于洲际旅行日益频繁,这一现象也在增多。新兴的耐抗生素淋病菌株尤其与东南亚旅行者的国际传播有关。感染淋病可引发一系列相关疾病,如皮炎、关节炎和化脓性关节炎以及盆腔炎,甚至会给个人带来严重的健康后果。自然感染不会产生免疫力,目前也没有疫苗可用,不过在一些国家,有报道称抗脑膜炎球菌疫苗可能对淋病有预防作用。实施所有必要的预防措施至关重要,同时还需要采用适当及时的诊断方法以及正确模式下有效的抗菌治疗手段,以避免对常见抗生素耐药且难以根除的淋病形式增多。

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