Biocenter, Johannes Gutenberg University, Hanns-Dieter-Hüsch Weg 17, 55128 Mainz, Germany; Institute for Molecular Biology, Ackermannweg 4, 55128 Mainz, Germany.
Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA; Center of Excellence for Data Driven Discovery, Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Mol Cell. 2024 Apr 4;84(7):1188-1190. doi: 10.1016/j.molcel.2024.02.024.
In his commentary in this issue of Molecular Cell, Struhl reasons that the term "intrinsically disordered regions" represents a vague and confusing concept for protein function. However, the term "intrinsically disordered" highlights the important physicochemical characteristic of conformational heterogeneity. Thus, "intrinsically disordered" is the counterpart to the term "folded, " with neither term having specific functional implications.
在本期《分子细胞》的评论中，斯特鲁赫认为“无规则区域”这一术语代表了一个模糊和混淆的蛋白质功能概念。然而，“无规则”一词突出了构象异质性的重要物理化学特性。因此，“无规则”是“折叠”的对应词，两者都没有特定的功能含义。
