Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Mol Cell. 2024 Apr 4;84(7):1186-1187. doi: 10.1016/j.molcel.2024.02.023.
The term "intrinsically disordered region" (IDR) in proteins has been used in numerous publications. However, most proteins contain IDRs, the term refers to very different types of structures and functions, and many IDRs become structured upon interaction with other biomolecules. Thus, IDR is an unnecessary, vague, and ultimately confusing concept.
蛋白质中的“无规则区域”（IDR）一词在众多出版物中被广泛使用。然而，大多数蛋白质都含有 IDR，这个术语指的是非常不同类型的结构和功能，并且许多 IDR 在与其他生物分子相互作用时会变得有结构。因此，IDR 是一个不必要的、模糊的、最终令人困惑的概念。
