降低高尿酸血症和痛风的风险与理想的心血管健康相关。

Lowering the risk of hyperuricemia and gout is associated with ideal cardiovascular health.

机构信息

Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Department of Emergency, Jining No.1 People's Hospital, Jining, China.

出版信息

J Health Popul Nutr. 2024 Oct 24;43(1):167. doi: 10.1186/s41043-024-00665-6.

DOI:10.1186/s41043-024-00665-6

PMID:39449072

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11520112/

Abstract

BACKGROUND

Hyperuricemia (HUA) and gout have been demonstrated as independent risk factors for cardiovascular disease. The relationship between the recently updated Life's Essentials 8 (LE8), which measures ideal cardiovascular health (CVH), and HUA and gout remains unclear. The aim of this study was to explore the relationship between CVH and the prevalence of HUA and gout among a nationally representative sample of US adults.

METHODS

This study utilized cross-sectional analysis of data from the National Health and Nutrition Examination Survey (NHANES) for the years 2007 to 2018. The CVH scores and their corresponding components were defined according to the guidelines established by the American Heart Association. The association between the LE8 score and both HUA and gout was assessed using weighted multivariable logistic and restricted cubic spline (RCS) models.

RESULTS

Among the 21,155 participants aged 20 years and older, the prevalence of HUA was 17.20% (95% CI, 16.05-18.36%), and the prevalence of gout was 3.58% (95% CI, 3.13-4.02%). After adjusting for potential confounders, compared to participants exhibiting low CVH, the multivariable adjusted odds ratio (OR) for HUA was 0.65 (95% CI, 0.56-0.75) in those with moderate CVH, and 0.25 (95% CI, 0.20-0.31) in those with high CVH. Additionally, compared to participants with low CVH, the multivariable adjusted OR for gout was 0.66 (95% CI, 0.53-0.81) in those with moderate CVH and 0.32 (95% CI, 0.20-0.50) in those with high CVH. The LE8 score exhibited a significant nonlinear negative association with HUA and linear negative correlation with gout. In subgroup analyses focusing on HUA, significant interactions were observed between LE8 score and age, sex, and CKD (P for interaction < 0.05). For gout, only a significant interaction between LE8 score and sex was observed (P for interaction < 0.05).

CONCLUSIONS

Among adults, there was a significant negative correlation between LE8 score and the prevalence of HUA and gout. Maintaining an ideal CVH may be beneficial in reducing the burden of HUA and gout.

摘要

背景

高尿酸血症（HUA）和痛风已被证实是心血管疾病的独立危险因素。最近更新的Life's Essentials 8（LE8）衡量理想心血管健康（CVH），与 HUA 和痛风之间的关系尚不清楚。本研究旨在探讨 CVH 与美国成年人全国代表性样本中 HUA 和痛风患病率之间的关系。

方法

本研究使用 2007 年至 2018 年全国健康和营养调查（NHANES）的横断面分析数据。根据美国心脏协会制定的指南定义 CVH 评分及其相应组成部分。使用加权多变量逻辑和受限立方样条（RCS）模型评估 LE8 评分与 HUA 和痛风之间的关联。

结果

在 21155 名 20 岁及以上的参与者中，HUA 的患病率为 17.20%（95%CI，16.05-18.36%），痛风的患病率为 3.58%（95%CI，3.13-4.02%）。在调整潜在混杂因素后，与 CVH 低的参与者相比，CVH 中度和高度的参与者发生 HUA 的多变量调整比值比（OR）分别为 0.65（95%CI，0.56-0.75）和 0.25（95%CI，0.20-0.31）。此外，与 CVH 低的参与者相比，CVH 中度和高度的参与者发生痛风的多变量调整 OR 分别为 0.66（95%CI，0.53-0.81）和 0.32（95%CI，0.20-0.50）。LE8 评分与 HUA 呈显著负相关，与痛风呈线性负相关。在关注 HUA 的亚组分析中，LE8 评分与年龄、性别和 CKD 之间存在显著的交互作用（P<0.05）。对于痛风，仅观察到 LE8 评分与性别之间存在显著的交互作用（P<0.05）。