Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, 681 Samsen Road, Dusit District, Bangkok, 10300, Thailand.
Women's Health Center, MedPark Hospital, Bangkok, Thailand.
Reprod Health. 2024 Apr 6;21(1):44. doi: 10.1186/s12978-024-01783-4.
While postpartum weight changes may affect the levels of metabolic parameters, the direct effects of weight changes in the postpartum period on changes in the prevalence rates of metabolic syndrome and its components remain unstudied. This study aimed to investigate the effects of postpartum weight changes between 6 weeks and 6 months on changes in the prevalence rates of metabolic syndrome and its components in women who have recently experienced gestational diabetes mellitus.
This prospective cohort study included 171 postpartum women with recent gestational diabetes mellitus, who underwent serial weight and metabolic risk factor assessments at 6 weeks and 6 months postpartum. Weight changes between these time points were classified as weight loss (> 2 kg), weight stability (± 2 kg), or weight gain (> 2 kg). Metabolic syndrome comprised the following metabolic risk factors: large waist circumference, elevated blood pressure, elevated fasting plasma glucose levels, high triglyceride levels, and low high-density lipoprotein cholesterol levels.
Of the 171 women in our cohort, 30 women (17.5%) lost > 2 kg of body weight, while 85 (49.7%) maintained a stable weight and 56 (32.8%) gained > 2 kg. The weight loss group experienced significant changes in the prevalence rates of the following metabolic risk factors compared to the weight stability and weight gain groups: large waist circumference (% change: - 26.7 vs - 5.9 vs 5.4, respectively; p = 0.004), elevated fasting plasma glucose levels (% change: - 3.4 vs 18.9 vs 26.8, respectively; p = 0.022), and high triglyceride levels (% change: - 30.0 vs 0 vs - 7.2, respectively; p = 0.024). A significantly greater decrease in the prevalence of metabolic syndrome was also found in the weight loss group than in the other two groups (% change: - 20.0 vs 11.8 vs 14.2, respectively; p = 0.002).
Weight changes from 6 weeks to 6 months postpartum significantly altered the prevalence rates of metabolic syndrome and its components in women with recent gestational diabetes mellitus. Early postpartum weight loss can reverse metabolic risk factors and reduce the prevalence of metabolic syndrome.
Thai Clinical Trials Registry: Registration no. TCTR20200903001. Date of registration: September 3, 2020. Date of initial participant enrolment: September 7, 2020.
产后体重变化可能会影响代谢参数水平，但产后体重变化对近期患有妊娠糖尿病女性的代谢综合征及其各组分的患病率变化的直接影响仍不清楚。本研究旨在探讨产后 6 周至 6 个月期间体重变化对近期患有妊娠糖尿病女性的代谢综合征及其各组分的患病率变化的影响。
本前瞻性队列研究纳入了 171 名近期患有妊娠糖尿病的产后女性，她们在产后 6 周和 6 个月时接受了连续的体重和代谢风险因素评估。将这些时间点之间的体重变化分为体重减轻（>2kg）、体重稳定（±2kg）或体重增加（>2kg）。代谢综合征包括以下代谢风险因素：大腰围、血压升高、空腹血糖水平升高、甘油三酯水平升高和高密度脂蛋白胆固醇水平降低。
在我们的队列中，171 名女性中有 30 名（17.5%）体重减轻了>2kg，85 名（49.7%）体重稳定，56 名（32.8%）体重增加了>2kg。与体重稳定和体重增加组相比，体重减轻组的以下代谢风险因素的患病率发生了显著变化：大腰围（%变化：-26.7 比-5.9 比 5.4，分别；p=0.004）、空腹血糖水平升高（%变化：-3.4 比 18.9 比 26.8，分别；p=0.022）和甘油三酯水平升高（%变化：-30.0 比 0 比-7.2，分别；p=0.024）。体重减轻组的代谢综合征患病率也显著低于其他两组（%变化：-20.0 比 11.8 比 14.2，分别；p=0.002）。
产后 6 周至 6 个月期间的体重变化显著改变了近期患有妊娠糖尿病女性的代谢综合征及其各组分的患病率。产后早期体重减轻可以逆转代谢风险因素并降低代谢综合征的患病率。
泰国临床试验注册处：注册号 TCTR20200903001。注册日期：2020 年 9 月 3 日。首次参与者入组日期：2020 年 9 月 7 日。
