Hikima Naoko, Watanabe Daisuke, Yamaguchi Takuji, Hu Ailing, Tabuchi Masahiro, Takase Hikari, Goto Kashia, Watanabe Amaka, Kawaharada Tsuyoshi, Mizushima Shinobu, Mizushima Akio
Department of Palliative Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
Department of Anesthesiology and Pain Medicine, Juntendo University Graduate School of Medicine, Tokyo 113-8421, Japan.
Neuro Endocrinol Lett. 2024 Apr 7;45(2):83-90.
This preliminary study aims to examine the effects of tomato juice, which can be easily consumed regularly, on the physical and psychological states of healthy adults in the Coronavirus era.
Prospective observational study.
Ten healthy adults (mean age, 39.7±4.2 years) who consumed 180 mL of tomato juice twice daily for 4 weeks were enrolled. Measurements were taken before and after 4 weeks of consumption for the items below. Five salivary stress biomarkers (cortisol, α-amylase, secretory immunoglobulin A, chromogranin A, and oxytocin) were measured using approximately 1ml of passively pooled saliva samples, which were stored at -20°C until measurement. Autonomic nervous system (ANS) activity was evaluated using an acceleration pulse wave meter. Skin moisture content and transepidermal water loss (TEWL) were measured using Multi Display devices® MDD4 with specific probes. Subjective psychological states were assessed using Profile of Mood Status (POMS2®) and a survey on skin condition was conducted.
As for salivary stress biomarkers, tomato juice intake reduced cortisol and significantly increased oxytocin levels (p = 0.0427). No significant changes were observed in ANS activity. POMS2® results showed a significant decrease in confusion and bewilderment (p = 0.0207). Skin moisture content increased significantly (p = 0.0011), whereas TEWL decreased. The skin condition survey revealed significant changes in 10 parameters.
Tomato juice, which can be easily consumed regularly, may alleviate the stress of healthy adults in the Coronavirus era, supported by positive changes in salivary stress biomarker levels, skin moisture content, TEWL, and POMS2® results of this preliminary study.
本初步研究旨在探讨可方便地定期饮用的番茄汁对新冠疫情时代健康成年人身体和心理状态的影响。
前瞻性观察性研究。
招募了10名健康成年人（平均年龄39.7±4.2岁），他们连续4周每天饮用两次180毫升番茄汁。在饮用4周前后对以下项目进行测量。使用约1毫升被动收集的唾液样本测量5种唾液应激生物标志物（皮质醇、α-淀粉酶、分泌型免疫球蛋白A、嗜铬粒蛋白A和催产素），样本保存在-20°C直至测量。使用加速度脉搏波仪评估自主神经系统（ANS）活动。使用带有特定探头的Multi Display devices® MDD4测量皮肤水分含量和经表皮水分流失（TEWL）。使用情绪状态量表（POMS2®）评估主观心理状态，并进行皮肤状况调查。
关于唾液应激生物标志物，摄入番茄汁可降低皮质醇水平，并显著提高催产素水平（p = 0.0427）。ANS活动未观察到显著变化。POMS2®结果显示困惑和迷茫显著减少（p = 0.0207）。皮肤水分含量显著增加（p = 0.0011），而TEWL降低。皮肤状况调查显示有10项参数发生了显著变化。
本初步研究中，唾液应激生物标志物水平、皮肤水分含量、TEWL以及POMS2®结果均出现积极变化，这表明可方便地定期饮用的番茄汁可能缓解新冠疫情时代健康成年人的压力。
