Department of Craniofacial Diagnostics & Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur, Malaysia.
Curr Top Med Chem. 2024;24(13):1158-1184. doi: 10.2174/0115680266294573240328050629.
There has been increased scientific interest in bioactive compounds and their synthetic derivatives to promote the development of antimicrobial agents that could be used sustainably and overcome antibiotic resistance.
We conducted this scoping review to collect evidence related to the antimicrobial potential of diverse natural compounds from Zingiberaceae plants and their synthetic derivatives. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews guidelines. The literature search was conducted using PubMed, Web of Science and Scopus electronic databases for relevant studies published from 2012 to 2023. A total of 28 scientific studies fulfilled the inclusion criteria. The authors of these studies implemented and methods to examine the antimicrobial potency and underlying mechanisms of the investigated compounds.
The evidence elucidates the antimicrobial activity of natural secondary metabolites from Zingiberaceae species and their synthetic derivatives against a broad panel of gram-positive and gram-negative bacteria, fungi and viruses.
To date, researchers have proposed the application of bioactive compounds derived from Zingiberaceae plants and their synthetic analogues as antimicrobial agents. Nevertheless, more investigations are required to ascertain their efficacy and to broaden their commercial applicability.
人们对生物活性化合物及其合成衍生物越来越感兴趣，旨在开发可持续使用的、能够克服抗生素耐药性的抗菌剂。
我们进行了这项范围综述，以收集有关姜科植物中各种天然化合物及其合成衍生物的抗菌潜力的证据。我们遵循了系统评价和荟萃分析（PRISMA）扩展范围综述指南。文献检索使用了 PubMed、Web of Science 和 Scopus 电子数据库，以获取 2012 年至 2023 年发表的相关研究。共有 28 项科学研究符合纳入标准。这些研究的作者采用了各种方法来检测所研究化合物的抗菌效力和潜在机制。
这些证据阐明了姜科植物天然次生代谢物及其合成衍生物对多种革兰氏阳性和革兰氏阴性细菌、真菌和病毒的抗菌活性。
迄今为止，研究人员已经提出将姜科植物及其合成类似物衍生的生物活性化合物用作抗菌剂。然而，需要进一步的研究来确定它们的疗效，并扩大它们的商业适用性。
