Chen Yurao, Fan Peng, Chen Zhenhai, Zheng Zemao, He Ming, Zhao Xiang, Chen Ronghuai, Yao Juan, Yang Zhaodong
Department of Radiation Oncology, Huaian Hospital of Huaian City, Huaian, 223299, Jiangsu, China.
Department of General Surgery, Huaian Hospital of Huaian City, Huaian, 223299, Jiangsu, China.
Open Med (Wars). 2024 Apr 5;19(1):20240946. doi: 10.1515/med-2024-0946. eCollection 2024.
Esophageal squamous cell carcinoma (ESCC), a highly aggressive subtype of esophageal cancer, is characterized by late-stage diagnosis and limited treatment options. Recent advancements in transcriptome sequencing technologies have illuminated the molecular intricacies of ESCC tumors, revealing metabolic reprogramming as a prominent feature. Specifically, the Warburg effect, marked by enhanced glycolysis, has emerged as a hallmark of cancer, offering potential therapeutic targets. In this study, we comprehensively analyzed bulk RNA-seq data from ESCC patients, uncovering elevated expression in ESCC development and a poorer prognosis. Silencing of SRA1 led to a modulation of glycolysis-related products and a shift in PKM2 expression. Our findings shed light on the intricate molecular landscape of ESCC, highlighting SRA1 as a potential therapeutic target to disrupt glycolysis-dependent energy production. This metabolic reprogramming may hold the key to innovative treatment strategies for ESCC, ultimately improving patient outcomes.
食管鳞状细胞癌（ESCC）是一种侵袭性很强的食管癌亚型，其特点是诊断时已处于晚期且治疗选择有限。转录组测序技术的最新进展揭示了ESCC肿瘤的分子复杂性，表明代谢重编程是一个显著特征。具体而言，以糖酵解增强为特征的瓦伯格效应已成为癌症的一个标志，提供了潜在的治疗靶点。在本研究中，我们全面分析了ESCC患者的大量RNA测序数据，发现其在ESCC发展过程中表达升高且预后较差。沉默SRA1导致糖酵解相关产物的调节和PKM2表达的改变。我们的研究结果揭示了ESCC复杂的分子格局，突出了SRA1作为破坏糖酵解依赖的能量产生的潜在治疗靶点。这种代谢重编程可能是ESCC创新治疗策略的关键，最终改善患者预后。
