Arkar Ula, Vipotnik Vesnaver Tina, Osredkar Damjan, Perković Benedik Mirjana, Bizjak Neli
Department of Child, Adolescent and Developmental Neurology, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Department of Radiology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Front Neurol. 2024 Mar 22;15:1359938. doi: 10.3389/fneur.2024.1359938. eCollection 2024.
Pediatric onset multiple sclerosis (POMS) in the very young is a very rare entity and presents a difficult diagnostic challenge due to overlapping signs and symptoms with other diseases. We present a 4-year-old boy who initially presented with right-sided hemiparesis and demyelinating lesions on MRI. Follow-up MRI examinations 3 and 6 months later revealed new demyelinating lesions. Ten months after initial presentation, he presented with right-sided hemiparesis, central facial nerve palsy on the right side and new demyelinating lesions on MRI. Two clinical events and new MRI lesions on follow-up MRIs confirmed the diagnosis of POMS. He was treated with rituximab and experienced no further relapses or radiological progression during the follow-up period.
极幼年起病的儿童多发性硬化症（POMS）是一种非常罕见的病症，由于其体征和症状与其他疾病重叠，因此在诊断上面临挑战。我们报告一名4岁男孩，其最初表现为右侧偏瘫，MRI显示有脱髓鞘病变。3个月和6个月后的随访MRI检查发现了新的脱髓鞘病变。首次就诊10个月后，他再次出现右侧偏瘫、右侧中枢性面神经麻痹，MRI显示有新的脱髓鞘病变。两次临床事件以及随访MRI上出现的新病变证实了POMS的诊断。他接受了利妥昔单抗治疗，在随访期间未出现进一步复发或影像学进展。
