: unprecedented L-dopa content and its role in neurodegenerative and inflammatory conditions.

UNLABELLED

Genus encompasses several plant species renowned for their utilization in traditional Ayurvedic medicine for the treatment of Parkinson's disease, chiefly due to their exceptionally high L-dopa content relative to other plants. However, limited information exists regarding , a newly identified species within the genus. This study unveils a remarkable L-dopa content of 174.3 mg/g in seeds, surpassing all previously documented species. Moreover, this research marks the first documentation of L-dopa, flavonoids, and phenolics within seeds. Furthermore, the aqueous extract derived from these seeds exhibits robust antioxidant properties. Investigation into its anti-inflammatory potential reveals a significant reduction in paw swelling and neutrophil infiltration at inflammatory sites in a carrageenan-induced rat model. Gene expression analysis utilizing a rat paw model demonstrates that the seed extract significantly downregulates the expression of various inflammation-related genes compared to carrageenan-treated rats. Collectively, these findings clearly substantiate the anti-inflammatory activity of seed extract. The exceptional L-dopa content combined with its anti-inflammatory properties position seeds as a promising therapeutic option for neurodegenerative diseases like Parkinson's, as well as various inflammatory conditions.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1007/s13205-024-03969-w.