Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, China.
Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China.
Cell Mol Neurobiol. 2020 Oct;40(7):1067-1073. doi: 10.1007/s10571-020-00799-1. Epub 2020 Jan 28.
Spinal cord injury leads to loss of sensory motor functions below the damaged area, and can significantly affects physical and mental health. An effective spinal cord injury treatment is currently unavailable, in part, because of the intricacy of the brain, as well as the complex pathophysiological mechanism of the injury. Inflammation is an important biological process in multitudinous diseases, with no exception for spinal cord injury. Nuclear factor kappa beta (NF-κB) signaling pathway is a key inflammatory element, as it is involved in cell survival, apoptosis, proliferation, differentiation, and immune response. Activation of the NF-κB signaling pathway leads to the release of a large number of inflammatory factors that can affect tissue repair. Hence, the inhibition of inflammatory responses could improve the repair of injured spinal cord tissues. Secretory leukocyte protease inhibitor (SLPI) has anti-inflammatory and anti-bacterial properties, and promotes wound healing. SLPI can bind to the promoter region of tumor necrosis factor-αand interleukin-8 (IL-8) to inhibit the NF-κB signaling pathway. Additionally, SLPI can reduce secondary damages after spinal cord injury, and prevent further complications. In this report, we analyze the pathophysiological mechanism of spinal cord injury, the role of NF-κB signaling pathway following spinal cord injury, and how SLPI regulates the NF-κB signaling pathway to curtail inflammatory reaction.
脊髓损伤导致损伤区域以下的感觉运动功能丧失，并会显著影响身心健康。目前尚无有效的脊髓损伤治疗方法，部分原因是大脑的复杂性以及损伤的复杂病理生理机制。炎症是多种疾病中的一个重要生物学过程，脊髓损伤也不例外。核因子 kappa beta（NF-κB）信号通路是一个关键的炎症元件，因为它参与细胞存活、凋亡、增殖、分化和免疫反应。NF-κB 信号通路的激活导致大量炎症因子的释放，这些因子会影响组织修复。因此，抑制炎症反应可以改善受损脊髓组织的修复。分泌白细胞蛋白酶抑制剂（SLPI）具有抗炎和抗菌特性，并促进伤口愈合。SLPI 可以与肿瘤坏死因子-α和白细胞介素-8（IL-8）的启动子区域结合，抑制 NF-κB 信号通路。此外，SLPI 可以减少脊髓损伤后的继发性损伤，并预防进一步的并发症。在本报告中，我们分析了脊髓损伤的病理生理机制、脊髓损伤后 NF-κB 信号通路的作用以及 SLPI 如何调节 NF-κB 信号通路以抑制炎症反应。
