Padilla Sergio, Ledesma Christian, García-Abellán Javier, García José Alberto, Fernández-González Marta, de la Rica Alba, Galiana Antonio, Gutiérrez Félix, Masiá Mar
Infectious Diseases Unit, Hospital General Universitario de Elche, Alicante, Spain.
Universidad Miguel Hernández de Elche, San Juan de Alicante, Spain.
iScience. 2024 Mar 19;27(4):109536. doi: 10.1016/j.isci.2024.109536. eCollection 2024 Apr 19.
This prospective study aimed to determine the prevalence of long COVID in patients hospitalized for SARS-CoV-2 infection from March 2020 to July 2022 and assess the impact of different viral lineages. A total of 2,524 patients were followed up for 12 months, with persistent symptoms reported in 35.2% at one month, decreasing thereafter. Omicron variant patients initially showed higher symptom intensity, but this trend diminished over time. Certain viral lineages, notably Delta lineages AY.126 and AY.43, and Omicron sublineages BA.1.17, BA.2.56, and BA.5.1, consistently correlated with more severe symptoms. Overall, long COVID prevalence and severity were similar across SARS-CoV-2 variants. Specific lineages may influence post-COVID sequelae persistence and severity.
这项前瞻性研究旨在确定2020年3月至2022年7月因感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）而住院的患者中长新冠的患病率，并评估不同病毒谱系的影响。总共2524名患者接受了12个月的随访，1个月时有35.2%的患者报告有持续症状，此后逐渐减少。感染奥密克戎变异株的患者最初症状强度较高，但这种趋势随着时间推移而减弱。某些病毒谱系，特别是德尔塔谱系AY.126和AY.43，以及奥密克戎亚谱系BA.1.17、BA.2.56和BA.5.1，始终与更严重的症状相关。总体而言，不同SARS-CoV-2变异株的长新冠患病率和严重程度相似。特定谱系可能会影响新冠后遗症的持续时间和严重程度。
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