Goyal Aman, Quazi Mohammed A, Syed Rayika, Ikram Hafiz Abdullah, Sheikh Farooq A, Farooq Asif, Sultan Sulaiman, Sheikh Abu Baker
Department of Internal Medicine, Seth Gordhandas Sunderdas Medical College and King Edward Memorial Hospital, Mumbai, IND.
Department of Psychiatry and Behavioral Sciences, University of New Mexico School of Medicine, Albuquerque, USA.
Cureus. 2024 Mar 5;16(3):e55601. doi: 10.7759/cureus.55601. eCollection 2024 Mar.
Introduction Existing data suggest an association between primary spontaneous pneumothorax (PSP) and cannabis consumption, although evidence remains controversial. Methods This study used the 2016-2019 National Inpatient Sample Database to examine inpatients with PSP, categorizing them as cannabis users and non-users. Multivariate regression analyzed continuous variables, chi-square assessed categorical variables, and logistic regression models were built. Propensity score matching (PSM) mitigated the confounding bias. Results A total of 399,495 patients with PSP were admitted during the study period (13,415 cannabis users and 386,080 non-cannabis users). Cannabis users were more likely to be younger (p<0.001) and male (p<0.001) with a lower risk of baseline comorbidities than non-users. Cannabis users had a lower risk of sudden cardiac arrest, vasopressor use, the development of acute kidney injury, venous thromboembolism, the requirement for invasive and non-invasive mechanical ventilation, hemodialysis, ventilator-associated pneumonia, and the need for a tracheostomy. Cannabis use was associated with a 3.4 days shorter hospital stay (p<0.001), as confirmed by PSM analysis (2.3 days shorter, p<0.001). Additionally, cannabis users showed a lower risk of in-hospital mortality (p<0.001), a trend maintained in the PSM analysis (p<0.001). Conclusions Our study revealed correlations suggesting that cannabis users with PSP might experience lower in-hospital mortality and fewer complications than non-cannabis users.
引言 现有数据表明原发性自发性气胸（PSP）与大麻消费之间存在关联，尽管证据仍存在争议。方法 本研究使用2016 - 2019年全国住院患者样本数据库来检查患有PSP的住院患者，将他们分为大麻使用者和非使用者。多变量回归分析连续变量，卡方检验评估分类变量，并建立逻辑回归模型。倾向得分匹配（PSM）减轻了混杂偏倚。结果 在研究期间，共有399495例PSP患者入院（13415例大麻使用者和386080例非大麻使用者）。大麻使用者更可能较年轻（p<0.001）且为男性（p<0.001），与非使用者相比，基线合并症风险更低。大麻使用者发生心脏骤停、使用血管加压药、发生急性肾损伤、静脉血栓栓塞、有创和无创机械通气需求、血液透析、呼吸机相关性肺炎以及气管切开需求的风险更低。大麻使用与住院时间缩短3.4天相关（p<0.001），PSM分析证实住院时间缩短2.3天（p<0.001）。此外，大麻使用者住院死亡率风险更低（p<0.001），PSM分析中这一趋势得以维持（p<0.001）。结论 我们的研究揭示了相关性，表明患有PSP的大麻使用者可能比非大麻使用者住院死亡率更低且并发症更少。
