可见光介导的异恶唑啉和异恶唑合成的三组分策略
Visible-Light-Mediated Three-Component Strategy for the Synthesis of Isoxazolines and Isoxazoles.
作者信息
Li Yanchuan, Zhang Yu, Wang Jinxin, Xia Dingding, Zhuo Miaomiao, Zhu Lu, Li Dong, Ni Shao-Fei, Zhu Yanping, Zhang Wei-Dong
机构信息
School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 310053, China.
Shanghai Frontiers Science Center for Chinese Medicine Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Shanghai 201203, China.
出版信息
Org Lett. 2024 Apr 19;26(15):3130-3134. doi: 10.1021/acs.orglett.4c00671. Epub 2024 Apr 8.
Isoxazolines and isoxazoles commonly serve as core structures of many therapeutic agents and natural products. However, the metal-free and catalysis-free strategy for the synthesis of these privileged motifs at room temperature remains a challenging task. Herein, we report a three-component strategy to afford diverse isoxazolines and isoxazoles via [3 + 2] cycloadditions of in situ-formed nitronates and olefins/alkynes under visible-light irradiation.
异恶唑啉和异恶唑通常是许多治疗剂和天然产物的核心结构。然而，在室温下无金属且无催化的策略来合成这些具有特殊结构的基序仍然是一项具有挑战性的任务。在此，我们报道了一种三组分策略，通过原位形成的硝酮与烯烃/炔烃在可见光照射下进行[3 + 2]环加成反应，以提供多种异恶唑啉和异恶唑。
Zotero 插件