Jessop J D, Wilkins M
J Rheumatol Suppl. 1979;5:137-42.
The effect of the gold salt, gold sodium thioglucose, has been studied on the phagocytic activity of tissue macrophages in synovium excised from patients with rheumatoid arthritis (RA) and maintained as explants in organ culture. Specimens of synovial membrane were taken for culture from synovial tissue excised from the knee joints of 22 patients with RA undergoing surgery and 14 menisectomy controls. Glass coverslips coated with yeast were placed on the synovium and the specimens maintained in organ culture. The phagocytic activity was assessed by counting the percentage of macrophages containing yeast on the coverslip removed after 24 hr in culture. The effect of gold salts was assessed by adding gold sodium thioglucose at concentrations of 3 and 30 microgram/ml to the medium, and using sodium thioglucose as an additional control. Results (means %) indicated significantly higher phagocytic activity in RA macrophages (68.6) compared with controls (40.1), p smaller than or equal to 0.001. Gold thioglucose significantly suppressed phagocytosis at 3 microgram/ml (48.0) p smaller than 0.01, and at 30 microgram/ml (47.7) p smaller than 0.02 in RA but had not effect on control synovium. Sodium thioglucose had no significant effect on phagocytosis at either concentration on RA synovium.
已对金盐硫代葡萄糖金钠对类风湿性关节炎（RA）患者切除的滑膜组织巨噬细胞吞噬活性的影响进行了研究，这些滑膜组织在器官培养中作为外植体保存。滑膜标本取自22例接受手术的RA患者膝关节切除的滑膜组织以及14例半月板切除术对照者。将涂有酵母的玻璃盖玻片放置在滑膜上，并将标本置于器官培养中。通过计算培养24小时后取出的盖玻片上含有酵母的巨噬细胞百分比来评估吞噬活性。通过向培养基中添加浓度为3和30微克/毫升的硫代葡萄糖金钠，并使用硫代葡萄糖钠作为额外对照来评估金盐的作用。结果（平均值%）表明，RA巨噬细胞的吞噬活性（68.6）显著高于对照组（40.1），p≤0.001。硫代葡萄糖金在3微克/毫升（48.0）时显著抑制吞噬作用，p<0.01，在30微克/毫升（47.7）时在RA中显著抑制吞噬作用，p<0.02，但对对照滑膜无影响。硫代葡萄糖钠在任何浓度下对RA滑膜的吞噬作用均无显著影响。
