Grandsoul Research Institute for Immunology, Inc., Utano, Uda, Nara 633-2221, Japan,
Faculty of Science, University of Toyama, Toyama, Toyama 930-8555, Japan.
Zoolog Sci. 2024 Feb;41(1):39-49. doi: 10.2108/zs230071.
Ghrelin is known to be a feeding stimulatory hormone in mammals, but in birds, in contrast to mammals, the feeding behavior is regulated in inhibitory manners. This is because the neuropeptides associated with the regulation in the brain are different from those in mammals, i.e., it has been shown that, in chickens, a corticotropin-releasing hormone family peptide, urocortin, which is a feeding-inhibitory peptide, is mainly involved in the inhibitory mechanism. However, feeding is also regulated by various neurotransmitters in the brain, and recently, their interaction with the mechanisms underlying feeding inhibition by ghrelin in birds has been intensively studied and clarified. This review summarizes these findings.
胃饥饿素被认为是哺乳动物的进食刺激激素，但与哺乳动物相反，鸟类的进食行为受到抑制调节。这是因为与大脑调节相关的神经肽与哺乳动物不同，即已经表明，在鸡中，促肾上腺皮质激素释放激素家族肽，促皮质素释放素，是一种进食抑制肽，主要参与抑制机制。然而，进食也受到大脑中各种神经递质的调节，最近，它们与鸟类中胃饥饿素抑制进食的机制的相互作用已得到深入研究和阐明。本综述总结了这些发现。
