Honma T, Saito T, Fujioka Y
Oral Surg Oral Med Oral Pathol. 1985 Apr;59(4):379-87. doi: 10.1016/0030-4220(85)90063-5.
Electron microscopic examination of the normal oral mucosa of patients with recurrent aphthous ulceration or Behçet's syndrome revealed that the degenerate dark prickle cells are apoptotic cells. Such dark prickle cells showed characteristic findings of apoptosis, such as the shrinkage of nucleus and cytoplasm and the formation of contraction vacuoles. The number of intraepithelial mononuclear cells phagocytosing apoptotic cellular debris increased remarkably at the preulcerative stage of the aphthous lesions. The apoptotic debris also attracted neutrophilic leukocytes in the prickle cell layer at the preulcerative stage but not in the normal oral epithelium. It is speculated that the onset of aphthous ulceration is closely related to phagocytosis of these apoptotic cells by intraepithelial mononuclear cells.
对复发性阿弗他溃疡或白塞病患者的正常口腔黏膜进行电子显微镜检查发现，退化的暗棘细胞是凋亡细胞。此类暗棘细胞呈现出凋亡的特征性表现，如细胞核和细胞质的收缩以及收缩泡的形成。在阿弗他病变的溃疡前期，吞噬凋亡细胞碎片的上皮内单核细胞数量显著增加。在溃疡前期，凋亡碎片也吸引了棘细胞层中的嗜中性白细胞，但在正常口腔上皮中则未出现这种情况。据推测，阿弗他溃疡的发病与上皮内单核细胞对这些凋亡细胞的吞噬密切相关。
