Honma T
Oral Surg Oral Med Oral Pathol. 1976 Mar;41(3):366-77. doi: 10.1016/0030-4220(76)90150-x.
In the prickle-cell layer of the oral epithelium of recurrent aphthous ulceration (RAU) the reticuloid cells with homogeneous, electron-lucent nuclei were attached to the degenerated prickle cells and ingested the cytoplasm of the prickle cells. The reticuloid cells came in contact with small lymphocytes, to which the immunologic information was transferred, inducing them to undergo blast transformation. Lymphoid cells, corresponding to T-cells, may produce a cytotoxic factor, since the prickle cells ultimately undergo degeneration. These changes are consistent with those of delayed hypersensitivity reactions. The cytoplasm of prickle cells apparently acts as an autoantigen. In Behçet's syndrome the macrophages were encountered in the epithelium. Other consequences were quite similar to those of RAU. The nucleus of the macrophage is more electron dense and has condensed chromatin along with the nuclear membrane. This can be a difference between Behçet's syndrome and RAU only at the initial stage of the diseases.
在复发性阿弗他溃疡（RAU）的口腔上皮棘细胞层中，具有均匀、电子透亮细胞核的类网状细胞附着于退化的棘细胞，并吞噬棘细胞的细胞质。类网状细胞与小淋巴细胞接触，将免疫信息传递给小淋巴细胞，诱导它们发生母细胞转化。由于棘细胞最终会发生退化，对应于T细胞的淋巴细胞可能会产生一种细胞毒性因子。这些变化与迟发型超敏反应的变化一致。棘细胞的细胞质显然充当自身抗原。在白塞病中，上皮中可见巨噬细胞。其他结果与RAU非常相似。巨噬细胞的细胞核电子密度更高，并且在核膜周围有浓缩的染色质。这可能只是白塞病和RAU在疾病初始阶段的一个区别。
