Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, HezarJarib Street, Isfahan 81746-73441, Iran.
Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science and Technology, University of Isfahan, HezarJarib Street, Isfahan 81746-73441, Iran.
Gene. 2024 Jul 20;916:148424. doi: 10.1016/j.gene.2024.148424. Epub 2024 Apr 7.
The most significant factors that lead to cancer-related death in breast cancer (BC) patients include drug resistance, migration, invasion, and metastasis. Several signaling pathways are involved in the development of BC. The different types of BC are initially sensitive to chemotherapy, and drug resistance can occur through multiple molecular mechanisms. Regardless of developing targeted Therapy, due to the heterogenic nature and complexity of drug resistance, it is a major clinical challenge with the low survival rate in BC patients. The deregulation of several signaling pathways, particularly the Hippo pathway (HP), is one of the most recent findings about the molecular mechanisms of drug resistance in BC, which are summarized in this review. Given that HP is one of the recent cancer research hotspots, this review focuses on its implication in BC drug resistance. Unraveling the different molecular basis of HP through its crosstalk with other signaling pathways, and determining the effectiveness of HP inhibitors can provide new insights into possible therapeutic strategies for overcoming chemoresistance in BC.
导致乳腺癌（BC）患者癌症相关死亡的最重要因素包括耐药性、迁移、侵袭和转移。几种信号通路参与了 BC 的发生发展。不同类型的 BC 最初对化疗敏感，耐药性可以通过多种分子机制发生。无论开发靶向治疗，由于异质性和耐药性的复杂性，这都是 BC 患者生存率低的主要临床挑战。几个信号通路的失调，特别是 Hippo 通路（HP），是关于 BC 耐药性分子机制的最新发现之一，本综述对此进行了总结。鉴于 HP 是癌症研究的最新热点之一，本综述重点关注其在 BC 耐药性中的意义。通过其与其他信号通路的相互作用来揭示 HP 的不同分子基础，并确定 HP 抑制剂的有效性，可以为克服 BC 化疗耐药性的可能治疗策略提供新的见解。
