Hippo 通路：癌症中的调控、失调及潜在治疗靶点。
Hippo pathway: Regulation, deregulation and potential therapeutic targets in cancer.
机构信息
Department of Biochemistry and Molecular Biology, LSUHSC, Shreveport, USA.
Department of Biochemistry and Molecular Biology, LSUHSC, School of Medicine, New Orleans, USA; Stanley S. Scott Cancer Center, LSUHSC, New Orleans, USA.
出版信息
Cancer Lett. 2021 Jun 1;507:112-123. doi: 10.1016/j.canlet.2021.03.006. Epub 2021 Mar 15.
Abstract
Hippo pathway is a master regulator of development, cell proliferation, stem cell function, tissue regeneration, homeostasis, and organ size control. Hippo pathway relays signals from different extracellular and intracellular events to regulate cell behavior and functions. Hippo pathway is conserved from Protista to eukaryotes. Deregulation of the Hippo pathway is associated with numerous cancers. Alteration of the Hippo pathway results in cell invasion, migration, disease progression, and therapy resistance in cancers. However, the function of the various components of the mammalian Hippo pathway is yet to be elucidated in detail especially concerning tumor biology. In the present review, we focused on the Hippo pathway in different model organisms, its regulation and deregulation, and possible therapeutic targets for cancer treatment.
摘要
Hippo 通路是发育、细胞增殖、干细胞功能、组织再生、内稳态和器官大小控制的主要调节因子。Hippo 通路将来自不同细胞外和细胞内事件的信号传递到调节细胞行为和功能。Hippo 通路从原生动物到真核生物都是保守的。Hippo 通路的失调与许多癌症有关。Hippo 通路的改变导致癌症中的细胞侵袭、迁移、疾病进展和治疗耐药性。然而，哺乳动物 Hippo 通路的各个组成部分的功能尚未详细阐明，特别是关于肿瘤生物学。在本综述中，我们重点介绍了不同模式生物中的 Hippo 通路、其调控和失调以及癌症治疗的可能治疗靶点。
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