Department of Public Health Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, 56000, Cheras, Wilayah Persekutuan Kuala Lumpur, Malaysia.
Department of Management, Faculty of Business, Universiti Teknologi MARA (UiTM) Kedah Branches, Campus Sg. Petani, 08400, Merbok, Kedah, Malaysia.
Sci Rep. 2024 Apr 8;14(1):8152. doi: 10.1038/s41598-024-58844-8.
The EQ-5D is a common generic tool used in clinical trials and economic evaluations to evaluate the health-related quality of life as a proxy of health outcomes. To date, studies using EQ-5D-5L to evaluate the health status of cancer patients remain scarce in Malaysia. In this study, EQ-5D-5L dimensions, EQ-5D-5L index, and EQ-VAS scores were applied to assess the health status of Malaysian cancer patients. A cross-sectional study was conducted March-December 2022 to collect data relevant to the EQ-5D-5L valuation of health status via the Research Electronic Data Capture (REDCap) platform. Respondents rated their health states using EQ-5D-5L and EQ-VAS. Among the 235 respondents, the mean EQ-5D-5L index and EQ-VAS score were 0.76 (SD 0.223) and 81.06 (SD 16.36). Most of the patients reported some problems in the pain/discomfort and anxiety/depression dimensions. The level of education, stage of cancer, and comorbidity were significantly associated with better health status on EQ-5D-5L (p < 0.05) but only the stage of cancer was significantly associated with EQ-VAS scores. This study highlighted the disparities in self-reported health status across patients of different sociodemographic and medical profiles with EQ-5D-5L valuation. Thus, future research should use EQ-5D norm scores as a benchmark of comparison among cancer patients.
EQ-5D 是一种常用于临床试验和经济评估的通用工具，用于评估健康相关生活质量，作为健康结果的替代指标。迄今为止，在马来西亚，使用 EQ-5D-5L 评估癌症患者健康状况的研究仍然很少。在这项研究中，EQ-5D-5L 维度、EQ-5D-5L 指数和 EQ-VAS 评分被用于评估马来西亚癌症患者的健康状况。一项横断面研究于 2022 年 3 月至 12 月进行，通过 Research Electronic Data Capture（REDCap）平台收集与 EQ-5D-5L 健康状况估值相关的数据。受访者使用 EQ-5D-5L 和 EQ-VAS 对他们的健康状况进行评分。在 235 名受访者中，EQ-5D-5L 指数和 EQ-VAS 评分的平均值分别为 0.76（SD 0.223）和 81.06（SD 16.36）。大多数患者在疼痛/不适和焦虑/抑郁维度报告了一些问题。教育程度、癌症分期和合并症与 EQ-5D-5L 上更好的健康状况显著相关（p<0.05），但只有癌症分期与 EQ-VAS 评分显著相关。这项研究强调了 EQ-5D-5L 评估中不同社会人口学和医疗特征的患者之间自我报告健康状况的差异。因此，未来的研究应该使用 EQ-5D 标准分数作为癌症患者之间的比较基准。
