• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

杂种的配子发生途径的周期性转换取决于其倍性水平。

A cyclical switch of gametogenic pathways in hybrids depends on the ploidy level.

机构信息

Laboratory of Non-Mendelian Evolution, Institute of Animal Physiology and Genetics of the CAS, Liběchov, Czech Republic.

Division of EcoScience, Ewha Womans University, Seoul, South Korea.

出版信息

Commun Biol. 2024 Apr 8;7(1):424. doi: 10.1038/s42003-024-05948-6.

DOI:10.1038/s42003-024-05948-6
PMID:38589507
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11001910/
Abstract

The cellular and molecular mechanisms governing sexual reproduction are conserved across eukaryotes. Nevertheless, hybridization can disrupt these mechanisms, leading to asexual reproduction, often accompanied by polyploidy. In this study, we investigate how ploidy level and ratio of parental genomes in hybrids affect their reproductive mode. We analyze the gametogenesis of sexual species and their diploid and triploid hybrids from the freshwater fish family Cobitidae, using newly developed cytogenetic markers. We find that diploid hybrid females possess oogonia and oocytes with original (diploid) and duplicated (tetraploid) ploidy. Diploid oocytes cannot progress beyond pachytene due to aberrant pairing. However, tetraploid oocytes, which emerge after premeiotic genome endoreplication, exhibit normal pairing and result in diploid gametes. Triploid hybrid females possess diploid, triploid, and haploid oogonia and oocytes. Triploid and haploid oocytes cannot progress beyond pachytene checkpoint due to aberrant chromosome pairing, while diploid oocytes have normal pairing in meiosis, resulting in haploid gametes. Diploid oocytes emerge after premeiotic elimination of a single-copied genome. Triploid hybrid males are sterile due to aberrant pairing and the failure of chromosomal segregation during meiotic divisions. Thus, changes in ploidy and genome dosage may lead to cyclical alteration of gametogenic pathways in hybrids.

摘要

有性生殖的细胞和分子机制在真核生物中是保守的。然而，杂交会破坏这些机制，导致无性繁殖，通常伴随着多倍体的产生。在这项研究中，我们研究了杂种中的多倍体水平和双亲基因组的比例如何影响它们的繁殖方式。我们使用新开发的细胞遗传学标记，分析了淡水鱼科 Cobitidae 中两性物种及其二倍体和三倍体杂种的配子发生。我们发现，二倍体杂种雌性具有原始（二倍体）和复制（四倍体）的卵原细胞和卵母细胞。由于配对异常，二倍体卵母细胞不能进入粗线期。然而，经前减数期基因组内复制产生的四倍体卵母细胞表现出正常的配对，产生二倍体配子。三倍体杂种雌性具有二倍体、三倍体和单倍体的卵原细胞和卵母细胞。由于染色体配对异常，三倍体和单倍体卵母细胞不能进入粗线期检查点，而二倍体卵母细胞在减数分裂中具有正常的配对，产生单倍体配子。二倍体卵母细胞在前减数期消除单个拷贝的基因组后出现。三倍体杂种雄性由于减数分裂过程中的配对异常和染色体分离失败而不育。因此，多倍体和基因组剂量的变化可能导致杂种配子发生途径的周期性改变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/5d6e1d726aef/42003_2024_5948_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/879406a5ce46/42003_2024_5948_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/f58e68f3766f/42003_2024_5948_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/f591dd305502/42003_2024_5948_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/711e23a62627/42003_2024_5948_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/110f6deb0b9e/42003_2024_5948_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/5d6e1d726aef/42003_2024_5948_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/879406a5ce46/42003_2024_5948_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/f58e68f3766f/42003_2024_5948_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/f591dd305502/42003_2024_5948_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/711e23a62627/42003_2024_5948_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/110f6deb0b9e/42003_2024_5948_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dff0/11001910/5d6e1d726aef/42003_2024_5948_Fig6_HTML.jpg

相似文献

1
A cyclical switch of gametogenic pathways in hybrids depends on the ploidy level.杂种的配子发生途径的周期性转换取决于其倍性水平。
Commun Biol. 2024 Apr 8;7(1):424. doi: 10.1038/s42003-024-05948-6.
2
Mutual maintenance of di- and triploid Pelophylax esculentus hybrids in R-E systems: results from artificial crossings experiments.R-E系统中二倍体和三倍体食用林蛙杂种的相互维持：人工杂交实验结果
BMC Evol Biol. 2017 Oct 17;17(1):220. doi: 10.1186/s12862-017-1063-3.
3
Aneuploid progenies of triploid hybrids between diploid and tetraploid loach Misgurnus anguillicaudatus in China.中国二倍体和四倍体泥鳅杂交三倍体的非整倍体后代。
Genetica. 2016 Oct;144(5):601-609. doi: 10.1007/s10709-016-9928-8. Epub 2016 Sep 22.
4
Maintenance of pure hybridogenetic water frog populations: Genotypic variability in progeny of diploid and triploid parents.维持纯杂交水蛙种群：二倍体和三倍体亲本后代的基因型变异性。
PLoS One. 2022 Jul 6;17(7):e0268574. doi: 10.1371/journal.pone.0268574. eCollection 2022.
5
Optional Endoreplication and Selective Elimination of Parental Genomes during Oogenesis in Diploid and Triploid Hybrid European Water Frogs.二倍体和三倍体杂交欧洲水蛙卵子发生过程中的选择性核内复制及亲本基因组的选择性消除
PLoS One. 2015 Apr 20;10(4):e0123304. doi: 10.1371/journal.pone.0123304. eCollection 2015.
6
Chromosomal rDNA Distribution Patterns in Clonal Triploid Hybrids (Teleostei, Cobitidae): Insights into Parental Genomic Contributions.克隆三倍体杂种（硬骨鱼纲，鳅科）的染色体核糖体DNA分布模式：对亲本基因组贡献的见解
Genes (Basel). 2025 Jan 9;16(1):68. doi: 10.3390/genes16010068.
7
Challenges and Costs of Asexuality: Variation in Premeiotic Genome Duplication in Gynogenetic Hybrids from Complex.无性生殖的挑战和代价：复杂基因组加倍在雌性单性生殖杂种中的表现。
Int J Mol Sci. 2021 Nov 9;22(22):12117. doi: 10.3390/ijms222212117.
8
Meiotic hybridogenesis in triploid Misgurnus loach derived from a clonal lineage.源自克隆谱系的三倍体泥鳅中的减数分裂杂交起源
Heredity (Edinb). 2008 Jun;100(6):581-6. doi: 10.1038/hdy.2008.17. Epub 2008 Apr 2.
9
The high diversity of gametogenic pathways in amphispermic water frog hybrids from Eastern Ukraine.乌克兰东部两性生殖水蛙杂种中配子发生途径的高度多样性。
PeerJ. 2022 Aug 23;10:e13957. doi: 10.7717/peerj.13957. eCollection 2022.
10
Variation in hybridogenetic hybrid emergence between populations of water frogs from the Pelophylax esculentus complex.杂交种水蛙种群之间杂种出现的杂种发生变异。
PLoS One. 2019 Nov 1;14(11):e0224759. doi: 10.1371/journal.pone.0224759. eCollection 2019.

引用本文的文献

1
Bimodal centromeres in pentaploid dogroses shed light on their unique meiosis.五倍体蔷薇的双峰着丝粒揭示了其独特的减数分裂过程。
Nature. 2025 Jun 18. doi: 10.1038/s41586-025-09171-z.
2
Natural repeated backcrosses lead to triploidy and tetraploidy in parthenogenetic butterfly lizards (Leiolepis: Agamidae).自然的反复回交导致孤雌生殖的蝴蝶蜥（Leiolepis：鬣蜥科）出现三倍体和四倍体。
Sci Rep. 2025 Jan 24;15(1):3094. doi: 10.1038/s41598-024-83300-y.
3
Lampbrush chromosomes of Danio rerio.斑马鱼的灯刷染色体。

本文引用的文献

1
Genetic and karyotype divergence between parents affect clonality and sterility in hybrids.父母之间的遗传和核型差异会影响杂种的克隆性和不育性。
Elife. 2023 Nov 6;12:RP88366. doi: 10.7554/eLife.88366.
2
Mechanisms of Intrinsic Postzygotic Isolation: From Traditional Genic and Chromosomal Views to Genomic and Epigenetic Perspectives.内在合子后隔离的机制：从传统的基因和染色体观点到基因组和表观遗传观点。
Cold Spring Harb Perspect Biol. 2023 Oct 3;15(10):a041607. doi: 10.1101/cshperspect.a041607.
3
Achiasmatic meiosis in the unisexual Amazon molly, Poecilia formosa.
Chromosome Res. 2025 Jan 16;33(1):2. doi: 10.1007/s10577-024-09761-z.
4
Gradual chromosomal lagging drive programmed genome elimination in hemiclonal fishes from the genus Hypseleotris.渐发性染色体滞后驱动半克隆鱼类 Hypseleotris 属中程序性基因组消除。
Sci Rep. 2024 Nov 6;14(1):26866. doi: 10.1038/s41598-024-78278-6.
5
Premeiotic endoreplication is the mechanism of obligate parthenogenesis in rock lizards of the genus .减数分裂前核内复制是岩蜥属中强制性孤雌生殖的机制。
Biol Lett. 2024 Sep;20(9):20240182. doi: 10.1098/rsbl.2024.0182. Epub 2024 Sep 18.
非减数分裂中的雌雄同体的亚马逊红腹食人鱼，Poecilia formosa。
Chromosome Res. 2022 Dec;30(4):443-457. doi: 10.1007/s10577-022-09708-2. Epub 2022 Dec 2.
4
Clonal gametogenesis is triggered by intrinsic stimuli in the hybrid's germ cells but is dependent on sex differentiation†.克隆配子发生是由杂种的生殖细胞中的内在刺激引发的，但依赖于性别分化。
Biol Reprod. 2022 Aug 9;107(2):446-457. doi: 10.1093/biolre/ioac074.
5
Premeiotic endoreplication is essential for obligate parthenogenesis in geckos.减数分裂前的内复制对于蜥蜴的强制性孤雌生殖是必不可少的。
Development. 2022 Apr 1;149(7). doi: 10.1242/dev.200345. Epub 2022 Apr 19.
6
Phylogeographic relationships and the evolutionary history of the Carassius auratus complex with a newly born homodiploid raw fish (2nNCRC).金鱼复合种群的系统地理关系和进化历史，以及一种新诞生的同源二倍体野生鱼（2nNCRC）。
BMC Genomics. 2022 Mar 28;23(1):242. doi: 10.1186/s12864-022-08468-x.
7
Challenges and Costs of Asexuality: Variation in Premeiotic Genome Duplication in Gynogenetic Hybrids from Complex.无性生殖的挑战和代价：复杂基因组加倍在雌性单性生殖杂种中的表现。
Int J Mol Sci. 2021 Nov 9;22(22):12117. doi: 10.3390/ijms222212117.
8
Delete and survive: strategies of programmed genetic material elimination in eukaryotes.删除并存活：真核生物中程序化遗传物质消除的策略。
Biol Rev Camb Philos Soc. 2022 Feb;97(1):195-216. doi: 10.1111/brv.12796. Epub 2021 Sep 20.
9
Genome Fractionation and Loss of Heterozygosity in Hybrids and Polyploids: Mechanisms, Consequences for Selection, and Link to Gene Function.基因组分馏和杂种及多倍体的杂合性丢失：机制、对选择的影响及其与基因功能的联系。
Mol Biol Evol. 2021 Dec 9;38(12):5255-5274. doi: 10.1093/molbev/msab249.
10
Sex chromosomes in meiotic, hemiclonal, clonal and polyploid hybrid vertebrates: along the 'extended speciation continuum'.有性生殖、半克隆、克隆和多倍体杂交脊椎动物中的性染色体：沿着“扩展的物种形成连续体”。
Philos Trans R Soc Lond B Biol Sci. 2021 Sep 13;376(1833):20200103. doi: 10.1098/rstb.2020.0103. Epub 2021 Jul 26.