过氧亚硝酸盐在晚期糖基化终产物介导的糖尿病心血管并发症中的调节作用
Regulatory role of peroxynitrite in advanced glycation end products mediated diabetic cardiovascular complications.
作者信息
Bala Asis
机构信息
Pharmacology and Drug Discovery Research Laboratory, Division of Life Sciences, Institute of Advanced Study in Science and Technology, Guwahati 781035, Assam, India.
出版信息
World J Diabetes. 2024 Mar 15;15(3):572-574. doi: 10.4239/wjd.v15.i3.572.
The Advanced Glycation End Products (AGE) binding with its receptor can increase reactive oxygen species (ROS) generation through specific signaling mediators. The effect of superoxide (O) and O mediated ROS and reactive nitrogen species depends on their concentration and location of formation. Nitric oxide (NO) has anti-inflammatory and anticoagulant properties and a vasodilation effect, but NO can be deactivated by reacting with O. This reaction between NO and O produces the potent oxidant ONOO. Therefore, ONOO-'s regulatory role in AGEs in diabetic cardiovascular complications must considered as a regulator of cardiovascular complications in diabetes.
晚期糖基化终末产物（AGE）与其受体结合可通过特定信号介质增加活性氧（ROS）的生成。超氧阴离子（O）和O介导的ROS及活性氮物质的作用取决于它们的浓度和生成位置。一氧化氮（NO）具有抗炎和抗凝特性以及血管舒张作用，但NO可与O反应而失活。NO与O之间的这种反应产生强氧化剂过氧亚硝酸盐（ONOO）。因此，必须将ONOO在糖尿病心血管并发症中对AGEs的调节作用视为糖尿病心血管并发症的一种调节因素。
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