Swank P R, Greenberg S D, Montalvo J, Hunter N R, Spjut H J, Estrada R, Winkler D G, Taylor G R
Acta Cytol. 1985 May-Jun;29(3):373-8.
Because the diagnosis of squamous-cell carcinoma of the lung by routine cytologic screening of sputum is often inconclusive, our laboratory is studying the use of cytomorphologic profiles as a reliable diagnostic aid. This study reports the analysis of the profiles of 75 subjects, both cigarette-smoking volunteers and hospitalized patients suspect for lung cancer. Twenty-five of the subjects had been classified as having squamous metaplasia, 25 as having atypias and 25 as having squamous-cell carcinoma. Four slides were made for each subject, with 100 random fields viewed on each slide. The frequency of free alveolar macrophages, metaplastic squamous cells, epithelial atypical cells and malignant squamous cells were noted for each field. The results indicated that, although there were large differences between individual profiles within each diagnostic category, there were significant differences between the average profiles for each diagnostic category. Furthermore, although there were differences in cell frequencies from slide to slide and within slides, the differences were constant across diagnostic categories. The results are supportive of the progressive-atypia hypothesis for squamous-cell carcinoma of the lung and provide a baseline for comparison with subsequent individual profiles.
由于通过痰液常规细胞学筛查诊断肺鳞状细胞癌往往难以确定，我们实验室正在研究使用细胞形态学特征作为可靠的诊断辅助手段。本研究报告了对75名受试者的特征分析，这些受试者包括吸烟志愿者和疑似肺癌的住院患者。其中25名受试者被归类为有鳞状化生，25名有非典型增生，25名有鳞状细胞癌。为每名受试者制作了4张玻片，每张玻片观察100个随机视野。记录每个视野中游离肺泡巨噬细胞、化生鳞状细胞、上皮非典型细胞和恶性鳞状细胞的出现频率。结果表明，虽然每个诊断类别内个体特征之间存在很大差异，但每个诊断类别的平均特征之间存在显著差异。此外，虽然玻片之间以及玻片内细胞频率存在差异，但这些差异在各诊断类别中是恒定的。这些结果支持了肺鳞状细胞癌的渐进性非典型增生假说，并为与后续个体特征进行比较提供了基线。
