Hosoki Minae, Hori Taiki, Kaneko Yousuke, Mori Kensuke, Yasui Saya, Tsuji Seijiro, Yamagami Hiroki, Kawata Saki, Hara Tomoyo, Masuda Shiho, Mitsui Yukari, Kurahashi Kiyoe, Harada Takeshi, Nakamura Shingen, Otoda Toshiki, Yuasa Tomoyuki, Kuroda Akio, Endo Itsuro, Matsuhisa Munehide, Aihara Ken-Ichi
Department of Internal Medicine, Anan Medical Center, 6-1 Kawahara, Takarada-cho, Tokushima 774-0045, Japan.
Department of Internal Medicine, Tokushima Prefectural Kaifu Hospital, 266 Sugitani, Nakamura, Tokushima 775-0006, Japan.
J Clin Med. 2024 Feb 24;13(5):1283. doi: 10.3390/jcm13051283.
Since diabetes and its complications have been thought to exaggerate cardiorenal disease, resulting in a short lifespan, we investigated causes of death and lifespans in individuals with and without diabetes at a Japanese community general hospital during the period from 2011 to 2020. Causes of death and age of death in individuals with and those without diabetes were compared, and associations between medications used and age of death were statistically analyzed. A total of 2326 deaths were recorded during the 10-year period. There was no significant difference between the mean ages of death in individuals with and those without diabetes. Diabetic individuals had higher rates of hepato-pancreatic cancer and cardio-renal failure as causes of death. The prescription rates of antihypertensives, antiplatelets, and statins in diabetic individuals were larger than those in non-diabetic individuals. Furthermore, the use of sulfonyl urea or glinides and insulin was independently and inversely associated with the age of death. In conclusion, individuals with diabetes were treated with comprehensive pharmaceutical interventions and had life spans comparable to those of individuals without diabetes. This study's discovery of an inverse relationship between the use of insulin secretagogues or insulin and the age of death suggests that the prevention of life-threatening hypoglycemia is crucial for individuals with diabetes.
由于糖尿病及其并发症被认为会加重心肾疾病，导致寿命缩短，我们调查了2011年至2020年期间日本一家社区综合医院中患糖尿病和未患糖尿病个体的死因和寿命。比较了患糖尿病和未患糖尿病个体的死因和死亡年龄，并对所用药物与死亡年龄之间的关联进行了统计分析。在这10年期间共记录了2326例死亡病例。患糖尿病和未患糖尿病个体的平均死亡年龄之间没有显著差异。糖尿病个体因肝胰腺癌和心肾衰竭导致死亡的比例更高。糖尿病个体中抗高血压药、抗血小板药和他汀类药物的处方率高于非糖尿病个体。此外，使用磺脲类或格列奈类药物以及胰岛素与死亡年龄呈独立负相关。总之，糖尿病个体接受了全面的药物干预，其寿命与非糖尿病个体相当。本研究发现胰岛素促泌剂或胰岛素的使用与死亡年龄之间存在负相关关系，这表明预防危及生命的低血糖对糖尿病个体至关重要。
