Ghanta V K, Hiramoto R N, Solvason H B, Spector N H
J Immunol. 1985 Aug;135(2 Suppl):848s-852s.
The effects of physical restraint and poly I:C treatment on the growth of MOPC 104E myeloma and murine osteosarcoma and survival of animals bearing such tumors were investigated. Our studies show that in the Balb/c mice with MOPC 104E myeloma the effects of restraint stress were detrimental and lead to early death of the mice. When the restraint was combined with poly I:C, during the early course of the disease, restraint stress neutralized the beneficial effects of the poly I:C treatment. These studies show that under certain circumstances, restraint stress can negate the effects of therapy. On the other hand, restraint stress produced an opposite effect in C3H/He mice with murine osteosarcoma tumor treated in the same fashion. In mice with osteosarcoma, restraint stress delayed tumor growth and increased the median survival time. When restraint stress was combined with poly I:C treatment, the mean tumor size was smaller and median survival was substantially increased over the control group. Because poly I:C therapy delayed tumor growth and increased survival in both models, efforts to strengthen this response were tested by conditioning. Our studies show the response to poly I:C as measured by elevation of the NK activity could be conditioned with camphor smell. Conditioning of the host to raise immune activity to alter the outcome of disease is a new area yet to be explored and has important clinical significance. These studies, we believe, are important because they explore the connection between mind and body and resistance to disease.
研究了物理束缚和聚肌胞苷酸（poly I:C）治疗对MOPC 104E骨髓瘤和小鼠骨肉瘤生长以及荷此类肿瘤动物存活的影响。我们的研究表明，在患有MOPC 104E骨髓瘤的Balb/c小鼠中，束缚应激的影响是有害的，会导致小鼠过早死亡。当束缚与poly I:C联合使用时，在疾病早期，束缚应激抵消了poly I:C治疗的有益效果。这些研究表明，在某些情况下，束缚应激可以抵消治疗效果。另一方面，以同样方式处理的患有小鼠骨肉瘤的C3H/He小鼠，束缚应激产生了相反的效果。在患有骨肉瘤的小鼠中，束缚应激延缓了肿瘤生长并延长了中位生存时间。当束缚应激与poly I:C治疗联合使用时，平均肿瘤大小更小，中位生存期比对照组显著延长。由于poly I:C治疗在两种模型中都延缓了肿瘤生长并提高了生存率，因此通过预处理来增强这种反应的努力进行了测试。我们的研究表明，通过樟脑气味可以预处理以提高自然杀伤细胞（NK）活性来衡量的对poly I:C的反应。预处理宿主以提高免疫活性以改变疾病结局是一个有待探索的新领域，具有重要的临床意义。我们认为这些研究很重要，因为它们探索了身心与抗病能力之间的联系。
