Ghanta V, Hiramoto R N, Solvason B, Spector N H
Ann N Y Acad Sci. 1987;496:637-46. doi: 10.1111/j.1749-6632.1987.tb35824.x.
We studied the effect of classical (Pavlovian) conditioning of the natural killer cell response on survival of tumor-bearing mice. Mice were given repeated injections of poly I:C every three days paired with exposure to the odor of camphor for 4 hours. First, we investigated the possible therapeutic effect of repeated exposure to the odor of camphor on the growth of MOPC 104E murine myeloma. The results indicate that camphor alone had no therapeutic effect when the mice were exposed to the odor of camphor after tumor transplantation. We then investigated the effect of repeated exposure to camphor prior to tumor transplantation and subsequent repeated exposure to camphor following tumor transplantation. Again, we observed no therapeutic benefit. In a third experiment, we examined the effect of the conditioned poly I:C response on the growth of the murine myeloma. Animals in the conditioned group had an increase in median survival (day 43, as compared to days 34, 38, 37 of various control groups). Two of these conditioned mice lived more than 120 days and showed early tumor growth, but were free of disease at day 97. During the course of the study conditioned mice received no additional treatment other than being reexposed to camphor every third day.
我们研究了自然杀伤细胞反应的经典（巴甫洛夫式）条件作用对荷瘤小鼠存活的影响。每隔三天给小鼠重复注射聚肌胞苷酸（poly I:C），同时让其暴露于樟脑气味中4小时。首先，我们研究了重复暴露于樟脑气味对MOPC 104E小鼠骨髓瘤生长的可能治疗效果。结果表明，在肿瘤移植后让小鼠暴露于樟脑气味时，单独使用樟脑没有治疗效果。然后我们研究了在肿瘤移植前重复暴露于樟脑以及在肿瘤移植后随后重复暴露于樟脑的效果。同样，我们未观察到治疗益处。在第三个实验中，我们检查了条件化的聚肌胞苷酸反应对小鼠骨髓瘤生长的影响。条件化组的动物中位生存期有所增加（第43天，相比之下各对照组为第34、38、37天）。这些条件化小鼠中有两只存活超过120天，且显示出早期肿瘤生长，但在第97天时无疾病。在研究过程中，条件化小鼠除了每隔三天再次暴露于樟脑外未接受其他额外治疗。
