Mohammed Farah A, Baban Rayah S, Jasim Mohsin A
Central Public Health Lab. / Ministry Of Health, Baghdad, Iraq.
Department of Chemistry and Biochemistry, College of Medicine, AL-Nahrain University, Baghdad, Iraq.
J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S406-S408. doi: 10.4103/jpbs.jpbs_632_23. Epub 2024 Feb 29.
This research investigates the gender-specific associations of uroguanylin levels with various health-related parameters in Iraqi adults. The results revealed significant differences between genders in food style preferences and waist circumference (WC) risk. Notably, uroguanylin exhibited distinct correlations with low density lipoprotein (LDL) cholesterol, glycated hemoglobin (HbA1c), body mass index (BMI), and WC in females and males, indicating potential gender-specific effects on lipid metabolism, glucose regulation, and adiposity. A total of 140 Iraqi adults (73 females and 67 males) were recruited into the study. Physical activity levels, food style preferences, WC risk, and BMI subgroups, were compared between genders. Additionally, participants' characteristics, including age, height, weight, BMI, blood pressure, cholesterol levels, and uroguanylin concentrations, were analyzed. Significant gender differences were observed in food style preferences, with a higher proportion of males preferring fast food, with a greater percentage of females classified as having a high risk, females exhibited lower height and weight compared to males. HbA1c levels were significantly lower in females, whereas high density lipoprotein (HDL) cholesterol levels were significantly higher in females than in males. Uroguanylin concentrations were also significantly lower in females compared to males. Uroguanylin shows a moderately negative correlation with LDL cholesterol in females but not in males. Furthermore, a strong negative association between uroguanylin and HbA1c in females indicated improved glycemic control with higher uroguanylin levels, whereas an opposite trend was observed in males. No significant association was observed between uroguanylin and BMI in females, a significant positive correlation was found in males. For WC, a weak negative correlation was noted in females, whereas a moderately negative correlation was observed in males. These contrasting correlations imply potential gender-specific effects of uroguanylin on adiposity and body fat distribution.
本研究调查了伊拉克成年人中尿鸟苷素水平与各种健康相关参数的性别特异性关联。结果显示，在饮食风格偏好和腰围（WC）风险方面存在显著的性别差异。值得注意的是，尿鸟苷素在女性和男性中与低密度脂蛋白（LDL）胆固醇、糖化血红蛋白（HbA1c）、体重指数（BMI）和WC呈现出不同的相关性，表明其对脂质代谢、血糖调节和肥胖可能存在性别特异性影响。共有140名伊拉克成年人（73名女性和67名男性）被纳入该研究。比较了男女之间的身体活动水平、饮食风格偏好、WC风险和BMI亚组。此外，还分析了参与者的特征，包括年龄、身高、体重、BMI、血压、胆固醇水平和尿鸟苷素浓度。在饮食风格偏好方面观察到显著的性别差异，男性中更喜欢快餐的比例更高，女性中被归类为高风险的比例更大，女性的身高和体重低于男性。女性的HbA1c水平显著较低，而女性的高密度脂蛋白（HDL）胆固醇水平显著高于男性。女性的尿鸟苷素浓度也显著低于男性。尿鸟苷素在女性中与LDL胆固醇呈中度负相关，而在男性中则无此相关性。此外，女性中尿鸟苷素与HbA1c之间存在强烈的负相关，表明尿鸟苷素水平较高时血糖控制得到改善，而在男性中观察到相反的趋势。女性中尿鸟苷素与BMI之间未观察到显著关联，男性中则发现显著的正相关。对于WC，女性中观察到弱负相关，而男性中观察到中度负相关。这些相反的相关性意味着尿鸟苷素对肥胖和体脂分布可能存在性别特异性影响。
