Kohno H, Iizuka Y, Suzuki T, Ohkubo Y, Kubodera A
J Nucl Med. 1985 Jul;26(7):761-4.
The developmental changes in the biodistribution of [67Ga]citrate were studied in rats. The uptake of 67Ga in many tissues changed clearly with age and the fluctuation pattern was characteristic in each tissue. The uptake in heart and bone decreased, but increased in epiphysis with development. In liver, a transient increase in 67Ga accumulation appeared in the course of growth. These changes in 67Ga uptake in tissues were in good agreement with the developmental changes in the levels of nucleotides or protein synthesis that have been found by a large number of studies. These results suggest the existence of a close relationship between 67Ga accumulation and the growth rate of tissues.
在大鼠中研究了[67Ga]柠檬酸盐生物分布的发育变化。许多组织中67Ga的摄取随年龄明显变化，且波动模式在每个组织中都具有特征性。心脏和骨骼中的摄取减少，但随着发育，骨骺中的摄取增加。在肝脏中，67Ga积累在生长过程中出现短暂增加。组织中67Ga摄取的这些变化与大量研究所发现的核苷酸或蛋白质合成水平的发育变化高度一致。这些结果表明67Ga积累与组织生长速率之间存在密切关系。
