青蒿素类药物的免疫抑制特性。
Immune suppressive properties of artemisinin family drugs.
作者信息
Hou Lifei, Huang Haochu
机构信息
Department of Medicine, Section of Rheumatology, and Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, United States.
Department of Medicine, Section of Rheumatology, and Knapp Center for Lupus and Immunology Research, University of Chicago, Chicago, IL, United States.
出版信息
Pharmacol Ther. 2016 Oct;166:123-7. doi: 10.1016/j.pharmthera.2016.07.002. Epub 2016 Jul 10.
Abstract
Artemisinin and its derivatives are the first-line antimalarial drugs, and have saved millions of lives across the globe, especially in developing world. The discovery of artemisinin by Youyou Tu was awarded the 2015 Nobel Prize in Physiology or Medicine. In addition to treating malaria, accumulating evidences suggest that artemisinin and its derivatives also possess potent anti-inflammatory and immunoregulatory properties. We recently showed that artesunate, an artemisinin analog, dramatically ameliorated autoimmune arthritis by selectively diminishing germinal center B cells. Herein, we review the immunosuppressive properties of artemisinin family drugs and the potential underlying mechanisms.
摘要
青蒿素及其衍生物是一线抗疟药物，在全球挽救了数百万人的生命，尤其是在发展中世界。屠呦呦发现青蒿素被授予2015年诺贝尔生理学或医学奖。除了治疗疟疾外，越来越多的证据表明青蒿素及其衍生物还具有强大的抗炎和免疫调节特性。我们最近发现，青蒿素类似物青蒿琥酯通过选择性减少生发中心B细胞，显著改善了自身免疫性关节炎。在此，我们综述青蒿素类药物的免疫抑制特性及其潜在的作用机制。
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