Gujar Mahekta R, Wang Hongyan
Neuroscience & Behavioral Disorders Programme, Duke-NUS Medical School, 8 College Road, 169857, Singapore.
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597, Singapore.
Oxf Open Neurosci. 2022 May 4;1:kvac001. doi: 10.1093/oons/kvac001. eCollection 2022.
The balance between proliferation and quiescence of stem cells is crucial in maintaining tissue homeostasis. Neural stem cells (NSCs) in the brain have the ability to be reactivated from a reversible quiescent state to generate new neurons. However, how NSCs transit between quiescence and reactivation remains largely elusive. larval brain NSCs, also known as neuroblasts, have emerged as an excellent model to study molecular mechanisms underlying NSC quiescence and reactivation. Here, we discuss our current understanding of the molecular mechanisms underlying the reactivation of quiescent NSCs in . We review the most recent advances on epigenetic regulations and microtubule cytoskeleton in quiescent NSCs and their cross-talk with signaling pathways that are required in regulating NSC reactivation.
干细胞增殖与静止之间的平衡对于维持组织稳态至关重要。大脑中的神经干细胞（NSCs）能够从可逆的静止状态重新激活以产生新的神经元。然而，神经干细胞如何在静止和重新激活之间转变仍 largely 难以捉摸。幼虫脑内的神经干细胞，也称为成神经细胞，已成为研究神经干细胞静止和重新激活潜在分子机制的优秀模型。在这里，我们讨论了目前对静止神经干细胞重新激活潜在分子机制的理解。我们回顾了静止神经干细胞中表观遗传调控和微管细胞骨架的最新进展，以及它们与调节神经干细胞重新激活所需信号通路的相互作用。
