Birt D F, Pour P M
J Natl Cancer Inst. 1985 Jul;75(1):127-33.
The influence of interactions between dietary fat and protein on spontaneous diseases was investigated in Syrian golden hamsters fed two levels of corn oil [4.5 or 18 g/385 kilocalories (kcal)] with each of two levels of casein (9 or 36 g/385 kcal). The four diets were fed to separate groups in two different sequences: 1) Diets were given during weeks 3-7 and followed by control diet (9 g corn oil and 18 g casein/385 kcal), or 2) control diet was fed during weeks 3-7, and the four diets were fed from week 8 until death. Dietary interactions of fat and protein modified spontaneous degenerative, inflammatory, and proliferative diseases in hamsters. For example, amyloidosis in the liver, kidneys, spleen, and adrenal glands was reduced in females by feeding high-fat-high-protein (HF-HP) diet in comparison with low-fat-high-protein (LF-HP) diet during weeks 3-7 or by feeding LP diets at either fat level after 8 weeks. The incidence of hepatic abscess was highest in males consuming HP diet at either fat level after 8 weeks, and hepatic necrosis was observed most often in hamsters fed HF-HP diet after 8 weeks. Gastric and renal vascular calcification and nephrocalcinosis incidences were reduced by 50-100% in hamsters fed HF-HP diet after 8 weeks, and HF diet fed at this time reduced vascular calcification in the heart in both sexes and in the lungs in males. Inflammation was generally influenced similarly by diets fed either during weeks 3-7 or after 8 weeks. In the prostate gland, inflammation was observed most frequently in males fed HF-LP diet; however, in the vagina inflammation was elevated in females fed HF-HP diet and found in the gallbladder more commonly in hamsters fed HF-HP than in those given LF-HP. The incidence of colitis was decreased by giving HF-LP diet during weeks 3-7 or LF-LP diets after week 8. The incidence of gastric ulcer was high in males fed HF diets during weeks 3-7, and intestinal ulcers were high in those fed LF-LP at this time. The adrenal hyperplasia incidence was highest in males given HF-HP diet before or after 8 weeks and in females given this diet after 8 weeks. Similarly, ovarian and hepatic ductal hyperplasia was highest in females fed HF-HP diet after 8 weeks, and gastric and intestinal hyperplasia increased with the rise in fat at both protein levels in both sexes.(ABSTRACT TRUNCATED AT 400 WORDS)
在叙利亚金仓鼠中研究了膳食脂肪与蛋白质之间的相互作用对自发性疾病的影响。给仓鼠喂食两种水平的玉米油[4.5或18克/385千卡（kcal）]，并分别搭配两种水平的酪蛋白（9或36克/385千卡）。将这四种饮食以两种不同顺序喂给不同的组：1）在第3 - 7周给予这些饮食，然后改为对照饮食（9克玉米油和18克酪蛋白/385千卡），或者2）在第3 - 7周喂对照饮食，从第8周直到死亡期间喂这四种饮食。脂肪和蛋白质的膳食相互作用改变了仓鼠的自发性退行性、炎症性和增殖性疾病。例如，与在第3 - 7周喂低脂高蛋白（LF - HP）饮食相比，雌性仓鼠在第3 - 7周喂高脂高蛋白（HF - HP）饮食，或在8周后喂任一脂肪水平的低蛋白（LP）饮食，肝脏、肾脏、脾脏和肾上腺的淀粉样变性都有所减少。8周后，食用任一脂肪水平高蛋白（HP）饮食的雄性仓鼠肝脓肿发病率最高，8周后喂HF - HP饮食的仓鼠肝坏死最常见。8周后喂HF - HP饮食的仓鼠胃和肾血管钙化及肾钙质沉着症发病率降低了50 - 100%，此时喂HF饮食降低了两性心脏和雄性肺部的血管钙化。在第3 - 7周或8周后喂食的饮食对炎症的影响通常相似。在前列腺中，喂HF - LP饮食的雄性仓鼠炎症最常见；然而，在阴道中，喂HF - HP饮食的雌性仓鼠炎症增加，在胆囊中，喂HF - HP饮食的仓鼠比喂LF - HP饮食的仓鼠更常见。在第3 - 7周喂HF - LP饮食或8周后喂LF - LP饮食可降低结肠炎发病率。在第3 - 7周喂HF饮食的雄性仓鼠胃溃疡发病率高，此时喂LF - LP饮食的仓鼠肠道溃疡发病率高。8周前后喂HF - HP饮食的雄性仓鼠和8周后喂这种饮食的雌性仓鼠肾上腺增生发病率最高。同样，8周后喂HF - HP饮食的雌性仓鼠卵巢和肝导管增生最高，两性在两种蛋白质水平下，胃和肠道增生都随脂肪增加而增加。（摘要截选至400字）
