Section of Rheumatology, Örnsköldsvik Hospital, Örnsköldsvik, Sweden.
Rheumatology, Department of Clinical Sciences, Malmö, Lund University, Jan Waldenströms Gata 1B, 205 02, Malmö, Sweden.
Clin Exp Med. 2024 Apr 10;24(1):75. doi: 10.1007/s10238-024-01335-x.
Spondyloarthritis (SpA) has been associated with comorbidities, e.g., cardiovascular disease. However, little is known about the relation between SpA and chronic obstructive pulmonary disease (COPD). The aim of the study was to compare the prevalence of COPD in SpA to the general population. Patients with prevalent SpA in Skåne, Sweden, on December 31, 2018, were identified based on diagnostic codes in a regional register on primary care, secondary outpatient care and inpatient care. Population-based controls (5 per SpA case) were matched for age, sex and municipality. The base case definition for COPD required at least two prior visits with a registered COPD diagnosis. Stricter definitions included dispensed prescriptions for COPD and a COPD diagnosis made by a specialist in lung medicine. The prevalence of COPD in patients with SpA and controls, overall and stratified by sex and age, and the corresponding prevalence ratios, were estimated. A total of 3571 patients with SpA (51% male, mean age 53 years) were compared to 17,855 matched controls. The prevalence of COPD in patients with SpA was 37.8/1000, with a prevalence ratio compared to controls of 1.03 (95% CI 0.85-1.24). There were no significant differences in COPD prevalence between patients with SpA and controls in men or women, in any of the age groups, or in analyses using stricter definitions of COPD. In this regional study including data from primary care, the prevalence of COPD was not increased in patients with SpA compared to the background population.
脊柱关节炎（SpA）与合并症有关，例如心血管疾病。然而，对于 SpA 与慢性阻塞性肺疾病（COPD）之间的关系知之甚少。本研究的目的是比较 SpA 患者中 COPD 的患病率与普通人群。2018 年 12 月 31 日，在瑞典斯科讷地区，根据初级保健、二级门诊和住院治疗的区域登记处的诊断代码，确定了患有现患 SpA 的患者。基于年龄、性别和市匹配了 5 名对照（每例 SpA 患者 1 名）。COPD 的基本病例定义至少需要两次有 COPD 诊断的就诊记录。更严格的定义包括 COPD 的处方和肺病专家做出的 COPD 诊断。估计了 SpA 患者和对照者中 COPD 的总体患病率以及按性别和年龄分层的患病率比，以及相应的患病率比。共比较了 3571 名 SpA 患者（51%为男性，平均年龄 53 岁）和 17855 名匹配对照者。SpA 患者的 COPD 患病率为 37.8/1000，与对照者相比的患病率比为 1.03（95%CI 0.85-1.24）。在男性或女性、任何年龄组或使用更严格的 COPD 定义的分析中，SpA 患者和对照者之间的 COPD 患病率均无显著差异。在这项包括初级保健数据的区域性研究中，与背景人群相比，SpA 患者的 COPD 患病率没有增加。
