Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA.
Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Med Phys. 2024 Aug;51(8):5754-5763. doi: 10.1002/mp.17071. Epub 2024 Apr 10.
While careful planning and pre-treatment checks are performed to ensure patient safety during external beam radiation therapy (EBRT), inevitable daily variations mean that in vivo dosimetry (IVD) is the only way to attain the true delivered dose. Several countries outside the US require daily IVD for quality assurance. However, elsewhere, the manual labor and time considerations of traditional in vivo dosimeters may be preventing frequent use of IVD in the clinic.
This study expands upon previous research using plastic scintillator discs for optical dosimetry for electron therapy treatments. We present the characterization of scintillator discs for in vivo x-ray dosimetry and describe additional considerations due to geometric complexities.
Plastic scintillator discs were coated with reflective white paint on all sides but the front surface. An anti-reflective, matte coating was applied to the transparent face to minimize specular reflection. A time-gated iCMOS camera imaged the discs under various irradiation conditions. In post-processing, background-subtracted images of the scintillators were fit with Gaussian-convolved ellipses to extract several parameters, including integral output, and observation angle.
Dose linearity and x-ray energy independence were observed, consistent with ideal characteristics for a dosimeter. Dose measurements exhibited less than 5% variation for incident beam angles between 0° and 75° at the anterior surface and 0-60 at the posterior surface for exit beam dosimetry. Varying the angle between the disc surface and the camera lens did not impact the integral output for the same dose up to 55°. Past this point, up to 75°, there is a sharp falloff in response; however, a correction can be used based on the detected width of the disc. The reproducibility of the integral output for a single disc is 2%, and combined with variations from the gantry angle, we report the accuracy of the proposed scintillator disc dosimeters as ±5.4%.
Plastic scintillator discs have characteristics that are well-suited for in vivo optical dosimetry for x-ray radiotherapy treatments. Unlike typical point dosimeters, there is no inherent readout time delay, and an optical recording of the measurement is saved after treatment for future reference. While several factors influence the integral output for the same dose, they have been quantified here and may be corrected in post-processing.
在进行外束放射治疗(EBRT)时,会进行精心的规划和预处理检查,以确保患者的安全,但不可避免的日常变化意味着体内剂量测量(IVD)是获得实际剂量的唯一方法。美国以外的几个国家要求进行日常 IVD 以确保质量。然而,在其他地方,传统体内剂量计的人工和时间考虑因素可能会阻止在临床中频繁使用 IVD。
本研究扩展了之前使用塑料闪烁体盘进行电子治疗的光剂量学研究。我们介绍了用于体内 X 射线剂量测量的闪烁体盘的特性,并描述了由于几何复杂性而导致的其他考虑因素。
塑料闪烁体盘的所有侧面(正面除外)都涂有反射白色油漆。在透明面上涂有抗反射、哑光涂料,以最大限度地减少镜面反射。在各种辐照条件下,使用时间门控 iCMOS 相机对圆盘进行成像。在后处理中,用高斯卷积椭圆拟合背景减去的闪烁体图像,以提取几个参数,包括积分输出和观察角度。
观察到剂量线性和 X 射线能量独立性,与剂量计的理想特性一致。对于前表面入射光束角度在 0°到 75°之间和后表面出射光束角度在 0°到 60°之间的剂量测量,变化小于 5%。改变圆盘表面和相机镜头之间的角度,在相同剂量下不会影响积分输出,最高可达 55°。超过此点,高达 75°,响应急剧下降;但是,可以根据检测到的圆盘宽度进行校正。单个圆盘的积分输出重复性为 2%,结合旋转架角度的变化,我们报告了所提出的闪烁体盘剂量计的准确性为±5.4%。
塑料闪烁体盘具有非常适合 X 射线放射治疗的体内光学剂量测量的特性。与典型的点剂量计不同,没有固有的读数延迟,并且在治疗后保存了测量的光学记录,以备将来参考。虽然有几个因素会影响相同剂量的积分输出,但这里已经对其进行了量化,并可以在后期处理中进行校正。