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本文引用的文献

1
Cherenkov video imaging allows for the first visualization of radiation therapy in real time.切伦科夫视频成像是实时可视化放射治疗的首次尝试。
Int J Radiat Oncol Biol Phys. 2014 Jul 1;89(3):615-22. doi: 10.1016/j.ijrobp.2014.01.046. Epub 2014 Mar 28.
2
Time-gated Cherenkov emission spectroscopy from linear accelerator irradiation of tissue phantoms.组织体模的线性加速器辐照的时门控切伦科夫发射光谱学。
Opt Lett. 2012 Apr 1;37(7):1193-5. doi: 10.1364/OL.37.001193.
3
Secondary neutron spectra from modern Varian, Siemens, and Elekta linacs with multileaf collimators.配备多叶准直器的现代瓦里安、西门子和医科达直线加速器产生的次级中子能谱。
Med Phys. 2009 Sep;36(9):4027-38. doi: 10.1118/1.3159300.
4
Activation processes in a medical linear accelerator and spatial distribution of activation products.医用直线加速器中的活化过程及活化产物的空间分布。
Phys Med Biol. 2006 Dec 21;51(24):N461-6. doi: 10.1088/0031-9155/51/24/N02. Epub 2006 Nov 30.

技术说明:医用直线加速器脉冲的时间选通:杂散辐射探测器。

Technical Note: Time-gating to medical linear accelerator pulses: Stray radiation detector.

机构信息

Thayer School of Engineering, Dartmouth College, Hanover, NH, 03755, USA.

DoseOptics LLC, Lebanon, NH, 03766, USA.

出版信息

Med Phys. 2019 Feb;46(2):1044-1048. doi: 10.1002/mp.13311. Epub 2018 Dec 14.

DOI:10.1002/mp.13311
PMID:30488442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7122787/
Abstract

PURPOSE

CCD cameras are employed to image scintillation and Cherenkov radiation in external beam radiotherapy. This is achieved by gating the camera to the linear accelerator (Linac) output. A direct output signal line from the linac is not always accessible and even in cases where such a signal is accessible, a physical wire connected to the output port can potentially alter Linac performance through electrical feedback. A scintillating detector for stray radiation inside the Linac room was developed to remotely time-gate to linac pulses for camera-based dosimetry.

METHODS

A scintillator coupled silicon photomultiplier detector was optimized and systematically tested for location sensitivity and for use with both x rays and electron beams, at different energies and field sizes. Cherenkov radiation emitted due to static photon beams was captured using the remote trigger and compared to the images captured using a wired trigger. The issue of false-positive event detection, due to additional neutron activated products with high energy beams, was addressed.

RESULTS

The designed circuit provided voltage >2.5 V even for distances up to 3 m from the isocenter with a 6 MV, 5 × 5 cm beam, using a Ø3 × 20 mm Bi Ge O (BGO) crystal. With a larger scintillator size, the detector could be placed even beyond 3 m distance. False-positive triggering was reduced by a coincidence detection scheme. Negligible fluctuations were observed in time-gated imaging of Cherenkov intensity emitted from a water phantom, when comparing directly connected vs this remote triggering approach.

CONCLUSION

The remote detector provides untethered synchronization to linac pulses. It is especially useful for remote Cherenkov imaging or remote scintillator dosimetry imaging during radiotherapeutic procedures when a direct line signal is not accessible.

摘要

目的

在外部束放射治疗中,使用 CCD 相机对闪烁和切伦科夫辐射进行成像。这是通过将相机门控到直线加速器(Linac)输出来实现的。并非总是可以访问直线加速器的直接输出信号线路,即使在可以访问此类信号的情况下,连接到输出端口的物理电线也可能通过电反馈改变直线加速器的性能。为了在直线加速器机房内对杂散辐射进行远程时间选通,开发了一种用于基于相机的剂量测定的闪烁探测器。

方法

优化了耦合硅光电倍增器探测器,并对其位置灵敏度进行了系统测试,以用于不同能量和射野大小的 X 射线和电子束。使用远程触发捕获由于静态光子束而发射的切伦科夫辐射,并将其与使用有线触发捕获的图像进行比较。解决了由于高能束产生的额外中子激活产物导致的假阳性事件检测问题。

结果

即使使用 6MV、5×5cm 射束,距离等中心 3m 远,使用 Ø3×20mm BiGeO(BGO)晶体,设计的电路也能提供 >2.5V 的电压。使用更大的闪烁体尺寸,探测器甚至可以放置在 3m 以外的距离。通过符合检测方案减少了假阳性触发。当比较直接连接与这种远程触发方法时,在水模体中发射的切伦科夫强度的定时门控成像中观察到可以忽略的波动。

结论

远程探测器为直线加速器脉冲提供了无束缚的同步。当无法访问直接线路信号时,它特别适用于远程切伦科夫成像或放射治疗过程中的远程闪烁体剂量测定成像。