van Steensel-Moll H A, Valkenburg H A, van Zanen G E
Am J Epidemiol. 1985 Feb;121(2):216-24. doi: 10.1093/oxfordjournals.aje.a113992.
To explore possible etiologic factors of childhood leukemia, a case-control study was performed in the Netherlands. Cases were selected from a complete nationwide register of cases of childhood leukemia which were diagnosed between 1973 and 1980. Controls were matched with cases for year of birth, sex, and place of residence at the time of diagnosis. Information about possible exposures was collected by a postal questionnaire addressed to the parents. This report concerns the results of the analysis of parental occupations and occupational exposures for 519 children with acute lymphocytic leukemia and 507 controls. During pregnancy, more mothers of patients were working in "hydrocarbon-related" occupations; relative risk (RR) = 2.5 (95% confidence interval (CI) = 0.7-9.4). Likewise, greater occupational exposure to chemicals (paint, petroleum products, and unspecified chemicals) during pregnancy was found for mothers of patients (RR = 2.4, 95% CI = 1.2-4.6). The kind of work being performed by the mothers one year before diagnosis did not differ between cases and controls. For the fathers, no relationship was found between a hydro-carbon-related occupation or occupational exposure to chemicals and leukemia in the offspring. Adjustment for birth order, social class, and degree of urbanization did not materially change the relative risks.
为探究儿童白血病可能的病因，在荷兰开展了一项病例对照研究。病例选自1973年至1980年间确诊的全国儿童白血病病例完整登记册。对照与病例在出生年份、性别及诊断时的居住地点方面进行匹配。通过向父母邮寄问卷收集有关可能暴露情况的信息。本报告涉及对519例急性淋巴细胞白血病患儿及507名对照的父母职业和职业暴露情况的分析结果。孕期，更多患儿的母亲从事“与碳氢化合物相关的”职业；相对危险度（RR）=2.5（95%置信区间（CI）=0.7 - 9.4）。同样，患儿母亲在孕期接触化学物质（油漆、石油产品及未明确的化学物质）的职业暴露程度更高（RR = 2.4，95% CI = 1.2 - 4.6）。病例组与对照组患儿母亲在诊断前一年所从事的工作类型并无差异。对于父亲而言，未发现从事与碳氢化合物相关职业或职业性接触化学物质与子代白血病之间存在关联。对出生顺序、社会阶层及城市化程度进行校正后，相对危险度无实质性改变。
