van Steensel-Moll H A, Valkenburg H A, van Zanen G E
Am J Epidemiol. 1986 Oct;124(4):590-4. doi: 10.1093/oxfordjournals.aje.a114431.
In the Netherlands, a nationwide register of children with leukemia formed the basis for a case-control study (1973-1980). Population controls were matched with the cases for the year of birth, sex, and place of residence at the time of diagnosis. The information was collected by mailed questionnaires addressed to the parents. The analyses concerned infectious diseases in the first year of life of children with acute lymphocytic leukemia and their controls. Common colds, periods of fever, and primary childhood infections showed relative risks (RR) of 0.8, 0.9, and 0.8, respectively, after adjustment for birth order, family size, social class, and residential space. Furthermore, fewer cases reported infectious diseases which required hospitalization in their first year of life (RR = 0.6, 95% confidence interval (CI) = 0.4-1.0). The general infection risk profile of children with acute lymphocytic leukemia is compatible with these findings: there were more first-born children among the patients (RR = 1.8; 95% CI = 1.1-2.7), more children from one-child families (RR = 1.4; 95% CI = 0.8-2.3), more children of parents with higher education (RR = 1.2; 95% CI = 0.9-1.5), and more rooms in patient's houses (RR = 1.4; 95% CI = 0.6-2.6).
在荷兰，一项针对白血病患儿的全国性登记成为了一项病例对照研究（1973 - 1980年）的基础。对照人群按照出生年份、性别和诊断时的居住地与病例进行匹配。信息通过邮寄给家长的问卷收集。分析涉及急性淋巴细胞白血病患儿及其对照在出生后第一年的传染病情况。在对出生顺序、家庭规模、社会阶层和居住空间进行调整后，普通感冒、发热期和儿童期原发性感染的相对风险（RR）分别为0.8、0.9和0.8。此外，报告在出生后第一年需要住院治疗的传染病的病例较少（RR = 0.6，95%置信区间（CI）= 0.4 - 1.0）。急性淋巴细胞白血病患儿的总体感染风险概况与这些发现相符：患者中头胎出生的儿童更多（RR = 1.8；95% CI = 1.1 - 2.7），独生子女家庭的儿童更多（RR = 1.4；95% CI = 0.8 - 2.3），父母受过高等教育的儿童更多（RR = 1.2；95% CI = 0.9 - 1.5），患者家中房间更多（RR = 1.4；95% CI = 0.6 - 2.6）。
