van Steensel-Moll H A, Valkenburg H A, Vandenbroucke J P, van Zanen G E
Int J Epidemiol. 1985 Dec;14(4):555-9. doi: 10.1093/ije/14.4.555.
An explorative case-control study was conducted in The Netherlands. The cases were obtained from a complete nationwide register of childhood leukaemia (1973-1980). Controls were matched with the cases for year of birth, sex and place of residence. Information about exposures of the mother to potential risk factors in the year before pregnancy and during pregnancy was collected via mailed questionnaires. The analyses concerned data on 519 patients with acute lymphocytic leukaemia and 507 controls. An association between maternal subfertility and childhood leukaemia might be suggested by several findings. A history of two or more miscarriages (OR 1.6; 95% Cl 1.0-2.7) and fertility problems (OR 6.0; 95% Cl 0.9-38.2) were more frequently reported among mothers of cases. The use of oral contraceptives (OC) was significantly higher (OR 1.3; 95% Cl 1.0-1.8) and the duration between discontinuation of OC and the relevant pregnancy was significantly longer. The OR for threatened abortion during the relevant pregnancy was 1.6 (95% Cl 1.0-2.6) and the related use of 'drugs to maintain pregnancy' was 1.9; 95% Cl 1.0-3.5. Among known risk factors, an increased OR for diagnostic irradiation was confirmed (OR 2.2; 95% Cl 1.2-3.8). No association between childhood leukaemia and prenatal viral infections, smoking and alcohol was found.
在荷兰进行了一项探索性病例对照研究。病例来自全国范围内完整的儿童白血病登记册（1973 - 1980年）。对照与病例在出生年份、性别和居住地点方面进行匹配。通过邮寄问卷收集母亲在怀孕前一年和怀孕期间接触潜在危险因素的信息。分析涉及519例急性淋巴细胞白血病患者和507例对照的数据。多项研究结果可能提示母亲生育力低下与儿童白血病之间存在关联。病例组母亲中报告有两次或更多次流产史（比值比1.6；95%可信区间1.0 - 2.7）和生育问题（比值比6.0；95%可信区间0.9 - 38.2）的情况更为常见。口服避孕药（OC）的使用显著更高（比值比1.3；95%可信区间1.0 - 1.8），且停用OC至相关怀孕之间的间隔时间显著更长。相关孕期先兆流产的比值比为1.6（95%可信区间1.0 - 2.6），“保胎药物”的相关使用比值比为1.9；95%可信区间1.0 - 3.5。在已知危险因素中，确诊诊断性照射的比值比升高得到证实（比值比2.2；95%可信区间1.2 - 3.8）。未发现儿童白血病与产前病毒感染、吸烟和饮酒之间存在关联。
