Division of Cardiology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nat Rev Cardiol. 2024 Sep;21(9):617-631. doi: 10.1038/s41569-024-01017-x. Epub 2024 Apr 10.
Cardiovascular disease (CVD) and cancer are among the leading causes of morbidity and mortality globally, and these conditions are increasingly recognized to be fundamentally interconnected. In this Review, we present the current epidemiological data for each of the modifiable risk factors shared by the two diseases, including hypertension, hyperlipidaemia, diabetes mellitus, obesity, smoking, diet, physical activity and the social determinants of health. We then review the epidemiological data demonstrating the increased risk of CVD in patients with cancer, as well as the increased risk of cancer in patients with CVD. We also discuss the shared mechanisms implicated in the development of these conditions, highlighting their inherent bidirectional relationship. We conclude with a perspective on future research directions for the field of cardio-oncology to advance the care of patients with CVD and cancer.
心血管疾病（CVD）和癌症是全球发病率和死亡率的主要原因，这些疾病越来越被认为是相互关联的。在这篇综述中，我们介绍了两种疾病共有的可改变的风险因素的当前流行病学数据，包括高血压、高脂血症、糖尿病、肥胖、吸烟、饮食、身体活动和健康的社会决定因素。然后，我们回顾了表明癌症患者 CVD 风险增加以及 CVD 患者癌症风险增加的流行病学数据。我们还讨论了这些疾病发展中涉及的共同机制，强调了它们固有的双向关系。最后，我们对心血管肿瘤学领域的未来研究方向进行了展望，以推进 CVD 和癌症患者的治疗。
