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在皮肤移植失败的情况下，冷大气等离子体是一种很有前景的替代治疗选择。

Cold Atmospheric Plasma Is a Promising Alternative Treatment Option in Case of Split Skin Graft Failure.

作者信息

Khabipov Aydar, Schreiber Andre, Kersting Stephan, Hummel Richard, Höhn Johannes, Partecke Lars-Ivo, Bekeschus Sander, Glitsch Anne, Keßler Wolfram

机构信息

Department of General, Visceral, Thoracic, and Vascular Surgery, Greifswald University Medical Center, Greifswald, Germany.

Department of General, Visceral, and Thoracic Surgery, Helios Clinic Schleswig, Schleswig, Germany.

出版信息

Case Rep Surg. 2024 Apr 3;2024:1013445. doi: 10.1155/2024/1013445. eCollection 2024.

DOI:10.1155/2024/1013445
PMID:38601320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11006453/
Abstract

Cold atmospheric plasma (CAP) has shown promising potential in promoting wound healing. This case report presents the successful application of CAP in a 42-year-old female patient with extensive wound healing disorders and superinfections following the excision of an abscess in the left thoracic region. After several failed split skin graft attempts, the implementation of CAP led to significant improvements in wound healing. This report highlights the wound healing-promoting effects of CAP and discusses its potential mechanisms of action.

摘要

冷大气等离子体（CAP）在促进伤口愈合方面已显示出有前景的潜力。本病例报告介绍了CAP在一名42岁女性患者中的成功应用，该患者在左胸区域脓肿切除后出现广泛的伤口愈合障碍和继发感染。在多次失败的分层皮片移植尝试后，CAP的应用使伤口愈合有了显著改善。本报告强调了CAP促进伤口愈合的作用，并讨论了其潜在的作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088b/11006453/c5d9824b3206/CRIS2024-1013445.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088b/11006453/75abef4dda6c/CRIS2024-1013445.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088b/11006453/c5d9824b3206/CRIS2024-1013445.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088b/11006453/75abef4dda6c/CRIS2024-1013445.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/088b/11006453/c5d9824b3206/CRIS2024-1013445.002.jpg

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Cold Atmospheric Plasma Is a Promising Alternative Treatment Option in Case of Split Skin Graft Failure.在皮肤移植失败的情况下，冷大气等离子体是一种很有前景的替代治疗选择。
Case Rep Surg. 2024 Apr 3;2024:1013445. doi: 10.1155/2024/1013445. eCollection 2024.
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本文引用的文献

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Cold atmospheric pressure plasma-antibiotic synergy in biofilms is mediated via oxidative stress response.冷大气压等离子体与抗生素在生物膜中的协同作用是通过氧化应激反应介导的。
Biofilm. 2023 Apr 7;5:100122. doi: 10.1016/j.bioflm.2023.100122. eCollection 2023 Dec.
2
Liquid plasma as a treatment for cutaneous wound healing through regulation of redox metabolism.液体等离子体通过调节氧化还原代谢治疗皮肤创伤愈合。
Cell Death Dis. 2023 Feb 13;14(2):119. doi: 10.1038/s41419-023-05610-9.
3
Treatment of Chronic Venous Ulcer with Cold Atmospheric Plasma Jet.
冷大气等离子体射流治疗慢性静脉溃疡
Case Rep Dermatol. 2022 Nov 11;14(3):344-349. doi: 10.1159/000527018. eCollection 2022 Sep-Dec.
4
Subcellular inactivation mechanisms of Pseudomonas aeruginosa treated by cold atmospheric plasma and application on chicken breasts.低温等离子体处理铜绿假单胞菌的亚细胞失活动力学及其在鸡胸肉上的应用。
Food Res Int. 2022 Oct;160:111720. doi: 10.1016/j.foodres.2022.111720. Epub 2022 Jul 30.
5
The evaluation of efficacy of atmospheric pressure plasma in diabetic ulcers healing: A randomized clinical trial.大气压等离子体治疗糖尿病溃疡的疗效评价：一项随机临床试验。
Dermatol Ther. 2021 Nov;34(6):e15169. doi: 10.1111/dth.15169. Epub 2021 Oct 29.
6
Medical gas plasma-stimulated wound healing: Evidence and mechanisms.医用气体等离子体刺激创面愈合：证据与机制。
Redox Biol. 2021 Oct;46:102116. doi: 10.1016/j.redox.2021.102116. Epub 2021 Aug 28.
7
The repetitive application of cold atmospheric plasma (CAP) improves microcirculation parameters in chronic wounds.重复应用冷等离体（CAP）可改善慢性伤口的微循环参数。
Microvasc Res. 2021 Nov;138:104220. doi: 10.1016/j.mvr.2021.104220. Epub 2021 Jun 30.
8
Cold atmospheric plasma improves cutaneous microcirculation in standardized acute wounds: Results of a controlled, prospective cohort study.冷大气压等离子体改善标准化急性创面的皮肤微循环：一项对照、前瞻性队列研究的结果。
Microvasc Res. 2021 Nov;138:104211. doi: 10.1016/j.mvr.2021.104211. Epub 2021 Jun 16.
9
Bacteria and Antibiotics in Wound Healing.细菌与创伤愈合中的抗生素
Surg Clin North Am. 2020 Aug;100(4):757-776. doi: 10.1016/j.suc.2020.05.007.
10
Plasma cupping induces VEGF expression in skin cells through nitric oxide-mediated activation of hypoxia inducible factor 1.血浆拔罐通过一氧化氮介导的缺氧诱导因子 1 激活诱导皮肤细胞中血管内皮生长因子的表达。
Sci Rep. 2019 Mar 7;9(1):3821. doi: 10.1038/s41598-019-40086-8.