Alharthi Ghaida Nawi A, Alzarei Ali
Department of Otolaryngology, Head and Neck Surgery, King Khalid University, Abha, SAU.
Otolaryngology - Head and Neck Surgery, Aseer Central Hospital, Abha, SAU.
Cureus. 2024 Mar 11;16(3):e55955. doi: 10.7759/cureus.55955. eCollection 2024 Mar.
Chronic rhinosinusitis (CRS) is marked by inflammation of the paranasal sinuses and mucosal lining of the nose. CRS can be classified as CRS with nasal polyps or CRS without polyps. In recent years, there has been increased attention on the immunological role of vitamin D in treating CRS, coupled with the observation of vitamin D deficiency among CRS patients. Vitamin D is acknowledged for its immunomodulatory properties, especially in allergic conditions. Recent studies suggest that individuals with CRS, especially those with CRS with nasal polyps, frequently demonstrate lower than normal levels of vitamin D. We conducted searches across various databases, including PubMed, Web of Science, ScienceDirect, and the Cochrane Library, both electronically and manually, to identify pertinent studies. Studies from 2003 to 2023 were included. Deficiency of vitamin D was considered with levels of vitamin D less than 30 ng/mL, and only original studies were included. Studies including patients taking vitamin D supplementation previously and patients with chronic kidney and liver diseases were excluded. We included nine studies that recruited 1,042 patients in total. More than half of the studies reported the presence of nasal polyps in CRS, and participants from four studies had CRS without nasal polyps. All of the included studies reported a negative correlation between levels of vitamin D and CRS. The majority of the studies depicted quite low levels of vitamin D among CRS patients. The degree of CRS severity as measured by endoscopic and radiological scores is moderately inversely correlated with vitamin D intake. Therefore, it is recommended that the relationship between various serum vitamin D concentrations and the severity of CRS be investigated in detail, along with an understanding of the cellular effects of vitamin D levels on the nasal mucosa.
慢性鼻-鼻窦炎（CRS）的特征是鼻窦和鼻黏膜的炎症。CRS可分为伴有鼻息肉的CRS或不伴有鼻息肉的CRS。近年来，维生素D在治疗CRS中的免疫作用受到了更多关注，同时也观察到CRS患者存在维生素D缺乏的情况。维生素D因其免疫调节特性而闻名，尤其是在过敏性疾病中。最近的研究表明，CRS患者，尤其是伴有鼻息肉的CRS患者，维生素D水平常常低于正常水平。我们通过电子和手动方式在多个数据库中进行检索，包括PubMed、科学网、ScienceDirect和Cochrane图书馆，以确定相关研究。纳入了2003年至2023年的研究。维生素D水平低于30 ng/mL被视为维生素D缺乏，且仅纳入原始研究。排除了包括之前服用维生素D补充剂的患者以及患有慢性肾脏和肝脏疾病的患者的研究。我们纳入了9项研究，共招募了1042名患者。超过一半的研究报告了CRS患者中存在鼻息肉，4项研究的参与者患有不伴有鼻息肉的CRS。所有纳入的研究均报告维生素D水平与CRS之间存在负相关。大多数研究描述CRS患者的维生素D水平相当低。通过内镜和放射学评分衡量的CRS严重程度与维生素D摄入量呈中度负相关。因此，建议详细研究各种血清维生素D浓度与CRS严重程度之间的关系，同时了解维生素D水平对鼻黏膜的细胞效应。
