Baruah Binayak, Gupta Ajay, Kumar Abhijit, Kumar Alok
Department of ENT, Tata Main Hospital, Jamshedpur, Jharkhand, India.
J Family Med Prim Care. 2020 Jun 30;9(6):2877-2879. doi: 10.4103/jfmpc.jfmpc_448_20. eCollection 2020 Jun.
Chronic Rhinosinusitis (CRS) is a chronic inflammatory disorder of the mucosal lining of the nose and paranasal sinuses. The ability of Vitamin D (VD3) to augment innate and adaptive immune responses has sparked interest in its immunologic role in the treatment of CRS. In this study, the incidence of vitamin D deficiency in CRS patients was compared to normal population and the beneficial role of Vitamin D supplementation in its treatment was also evaluated.
It is a retrospective 1-year study of 200 CRS patients with Vitamin D deficiency. The patients were divided into two groups, i.e. 100 patients were given oral Vitamin D supplements and the other group of 100 patients were treated as placebo. Both Vitamin D levels and the Total Nasal Symptom Score (TNSS) were assessed at the start and end of the study period.
Of the 200 subjects with CRS, 100 were given oral vitamin D supplementation in the form of Cholecalciferol 60000IU weekly once for 3 months and the other group were treated with placebo. Before the treatment, the average level of serum Vitamin D was 12.31 ng/ml. After 3 months, it increased significantly to 29.71 ng/ml. Similarly, the pretreatment TNSS score was on average 11.92. After 3 months, the scores fell by an average of 10.65 points, a significant statistical difference ( < 0.05).
There is a higher prevalence of vitamin D deficiency in CRS patients and that vitamin D supplementation in these patients went a long way in alleviating their symptoms.
慢性鼻-鼻窦炎（CRS）是一种发生于鼻腔和鼻窦黏膜衬里的慢性炎症性疾病。维生素D（VD3）增强先天性和适应性免疫反应的能力引发了人们对其在CRS治疗中免疫作用的兴趣。在本研究中，比较了CRS患者维生素D缺乏的发生率与正常人群，并评估了补充维生素D在其治疗中的有益作用。
这是一项对200例维生素D缺乏的CRS患者进行的为期1年的回顾性研究。患者分为两组，即100例患者给予口服维生素D补充剂，另一组100例患者接受安慰剂治疗。在研究期开始和结束时评估维生素D水平和总鼻症状评分（TNSS）。
在200例CRS受试者中，100例给予口服维生素D补充剂，形式为胆钙化醇60000IU，每周一次，共3个月，另一组接受安慰剂治疗。治疗前，血清维生素D平均水平为12.31 ng/ml。3个月后，显著升至29.71 ng/ml。同样，治疗前TNSS评分平均为11.92。3个月后，评分平均下降10.65分，有显著统计学差异（<0.05）。
CRS患者维生素D缺乏的患病率较高，补充维生素D对缓解这些患者的症状有很大帮助。
