FRCPath, Department of Histopathology, Liaquat National Hospital and Medical College, Karachi 74800, Pakistan.
Zainab Panjwani Memorial Hospital, Karachi 74800, Pakistan.
Dis Markers. 2024 Apr 3;2024:2540356. doi: 10.1155/2024/2540356. eCollection 2024.
Metaplastic breast carcinoma (MBC) is a rare subgroup of breast neoplasms associated with adverse outcomes because of its aggressive nature. Typically, MBCs show triple-negative hormone receptor (HR) status. Determining the HR status of breast cancer is an integral part because it is an important prognostic factor and helps in the treatment course of the disease. This study aimed to determine the HR status of MBC, its significance, and its association with various clinicopathological parameters.
This was a retrospective study conducted at the Department of Histopathology, Liaquat National Hospital. A total of 140 biopsy-proven cases of MBC were enrolled in the study. Clinical and pathological data were retrieved from the institutes' archives. Immunohistochemical studies were conducted to determine the estrogen receptor (ER) and progesterone receptor (PR) status.
The mean age of MBC in our population was found to be 52.18 ± 12.19 years. The HR positivity rate in our population was found to be 32.9%. A significant association was found between HR status and tumor laterality, tumor size, tumor grade, tumor stage, and recurrence. ER/PR-negative MBCs were most probably associated with higher grade and higher tumor stage and were larger in size (6.62 ± 3.43 cm) than ER/PR-positive MBCs (4.20 ± 1.88 cm). Moreover, ER/PR-positive MBCs showed a higher recurrence rate than ER/PR-negative MBCs (43.5% vs. 25.5%, respectively). No statistically significant relationship was found between HR status and patient age, histological subtype, or survival rate.
MBC is a rare breast neoplasm. MBC was found to be triple negative in most cases, but a significant percentage were HR (ER/PR) positive. Moreover, we found an association between HR status and various clinicopathological features, indicating that HR status is a significant predictor of MBC prognosis.
化生性乳腺癌（MBC）是一种罕见的乳腺肿瘤亚群，由于其侵袭性，与不良预后相关。MBC 通常表现为三阴性激素受体（HR）状态。确定乳腺癌的 HR 状态是不可或缺的一部分，因为它是一个重要的预后因素，并有助于疾病的治疗过程。本研究旨在确定 MBC 的 HR 状态、其意义以及与各种临床病理参数的关系。
这是在利亚卡特国家医院组织病理学系进行的回顾性研究。共纳入 140 例经活检证实的 MBC 病例。从机构档案中检索临床和病理数据。进行免疫组织化学研究以确定雌激素受体（ER）和孕激素受体（PR）状态。
我们人群中 MBC 的平均年龄为 52.18±12.19 岁。我们人群中 HR 阳性率为 32.9%。HR 状态与肿瘤侧别、肿瘤大小、肿瘤分级、肿瘤分期和复发之间存在显著关联。与 ER/PR 阴性 MBC 相比，ER/PR 阳性 MBC 更有可能具有更高的分级和更高的肿瘤分期，并且肿瘤更大（6.62±3.43cm）。此外，ER/PR 阳性 MBC 的复发率高于 ER/PR 阴性 MBC（分别为 43.5%和 25.5%）。HR 状态与患者年龄、组织学亚型或生存率之间无统计学显著关系。
MBC 是一种罕见的乳腺肿瘤。大多数情况下，MBC 为三阴性，但有相当比例的 HR（ER/PR）阳性。此外，我们发现 HR 状态与各种临床病理特征之间存在关联，表明 HR 状态是 MBC 预后的重要预测因子。
