Wang Shijing, Zhang Qingfu, Zhang Tangbo, Mao Xiaoyun
Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Department of Pathology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Oncol Lett. 2024 May 2;28(1):300. doi: 10.3892/ol.2024.14433. eCollection 2024 Jul.
Invasive papillary carcinoma (IPC) of the breast is a rare form of cancer. The current report documents a case of IPC characterized by a large tumor size and skin involvement. Surgical exploration revealed no evidence of axillary lymph node metastasis in breast cancer. Due to financial constraints, the patient opted solely for anastrozole endocrine therapy at a dosage of 1 mg/day for a period of 5 years post-surgery, foregoing other treatments such as radiotherapy and chemotherapy. Since discharge, 2.5 years have passed, during which the patient has been followed up via phone every 3 months, showing a good prognosis. A literature review indicated that IPC is prevalent amongst the elderly population and can be misdiagnosed due to its morphological, cytomorphological and immunophenotypic overlap with other types of papillary neoplasms. This tumor exhibits a more favorable prognosis compared with IDC, primarily attributed to its advantageous gene and molecular expression patterns, coupled with its decreased invasiveness. Despite limited evidence-based research on the treatment of IPC, the present case report, albeit with limitations, underscores the importance of avoiding over-treatment and suggests the feasibility of combining surgery with endocrine therapy for IPC.
乳腺浸润性乳头状癌（IPC）是一种罕见的癌症形式。本报告记录了一例以肿瘤体积大且累及皮肤为特征的IPC病例。手术探查显示乳腺癌无腋窝淋巴结转移迹象。由于经济限制，患者术后仅选择了阿那曲唑内分泌治疗，剂量为每日1毫克，持续5年，放弃了放疗和化疗等其他治疗。出院后已过去2.5年，在此期间通过每3个月一次的电话随访患者，显示预后良好。文献综述表明，IPC在老年人群中较为普遍，并且由于其在形态学、细胞形态学和免疫表型上与其他类型的乳头状肿瘤存在重叠，可能会被误诊。与浸润性导管癌（IDC）相比，这种肿瘤的预后更有利，主要归因于其有利的基因和分子表达模式，以及其侵袭性降低。尽管关于IPC治疗的循证研究有限，但本病例报告尽管存在局限性，仍强调了避免过度治疗的重要性，并提示了手术与内分泌治疗联合用于IPC的可行性。
