Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Durjava Mojca, Dusemund Birgit, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Villa Roberto Edoardo, Woutersen Ruud, Herman Lieve, Anguita Montserrat, Innocenti Matteo Lorenzo, Tarrés-Call Jordi, Pettenati Elisa
EFSA J. 2024 Apr 10;22(4):e8707. doi: 10.2903/j.efsa.2024.8707. eCollection 2024 Apr.
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l-tryptophan produced by fermentation with CGMCC 7.460 when used as a nutritional additive in feed and water for drinking for all animal species and categories. The production strain is not genetically modified. Viable cells of the production strain were not detected in the final additive. The additive does not give rise to any safety concern regarding the production strain. The use of l-tryptophan (≥ 98%) produced with CGMCC 7.460 to supplement feed is safe for non-ruminant species. There may be a risk for an increased production of toxic metabolites when unprotected tryptophan is used in ruminants. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) has concerns on the safety of the simultaneous oral administration of l-tryptophan via water for drinking and feed due to possible amino acid imbalances and hygienic reasons. The use of l-tryptophan produced with CGMCC 7.460 in animal nutrition raises no safety concerns to consumers of animal products and to the environment. In the absence of data, the FEEDAP Panel cannot conclude on the potential of the additive to be irritant to skin or eyes, or on its potential to be a dermal sensitiser. The endotoxin activity of the additive in combination with the high dusting potential may represent a risk of exposure by inhalation to endotoxins for users. The additive l-tryptophan is regarded as an effective source of the amino acid l-tryptophan for all non-ruminant species. To be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.
应欧盟委员会的要求，欧洲食品安全局（EFSA）被要求就一种饲料添加剂的安全性和有效性发表科学意见，该添加剂为由CGMCC 7.460发酵生产的L-色氨酸，用作所有动物种类和类别的饲料及饮用水中的营养添加剂。生产菌株未经过基因改造。在最终添加剂中未检测到生产菌株的活细胞。该添加剂不会引发与生产菌株有关的任何安全问题。使用由CGMCC 7.460生产的L-色氨酸（≥98%）补充饲料对非反刍动物是安全的。在反刍动物中使用未受保护的色氨酸时，可能存在产生有毒代谢物增加的风险。欧洲食品安全局动物饲料添加剂和产品或物质专家小组（FEEDAP）因可能的氨基酸失衡和卫生原因，对通过饮用水和饲料同时口服L-色氨酸的安全性表示担忧。在动物营养中使用由CGMCC 7.460生产的L-色氨酸对动物产品消费者和环境不存在安全问题。由于缺乏数据，FEEDAP小组无法就该添加剂对皮肤或眼睛的刺激性潜力或其成为皮肤致敏剂的潜力得出结论。该添加剂的内毒素活性与高扬尘潜力可能对使用者构成吸入内毒素的暴露风险。添加剂L-色氨酸被视为所有非反刍动物的氨基酸L-色氨酸的有效来源。为了在反刍动物中与在非反刍动物中一样有效，它应受到保护以免在瘤胃中降解。
