Bampidis Vasileios, Azimonti Giovanna, Bastos Maria de Lourdes, Christensen Henrik, Dusemund Birgit, Fašmon Durjava Mojca, Kouba Maryline, López-Alonso Marta, López Puente Secundino, Marcon Francesca, Mayo Baltasar, Pechová Alena, Petkova Mariana, Ramos Fernando, Sanz Yolanda, Villa Roberto Edoardo, Woutersen Ruud, Cocconcelli Pier Sandro, Glandorf Boet, Herman Lieve, Maradona Miguel Prieto, Saarela Maria, Anguita Montserrat, Galobart Jaume, Holczkencht Orsolya, Manini Paola, Pettenati Elisa, Pizzo Fabiola, Tarrés-Call Jordi
EFSA J. 2021 Mar 8;19(3):e06425. doi: 10.2903/j.efsa.2021.6425. eCollection 2021 Mar.
Following a request from the European Commission, the Panel on Additives and Products or substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of l-tryptophan produced by fermentation with KCCM 80210 when used as a nutritional additive in feed for all animal species and categories. The production strain KCCM 80210 is safe for the production of l-tryptophan and it was not detected in the final product. The Panel notes that two out of five batches of the additive do not comply with the minimum specification of 98% l-tryptophan on a dry matter basis proposed by the applicant. The use of l-tryptophan (≥ 98%) produced by KCCM 80210 in supplementing feed to compensate for l-tryptophan deficiency in feedingstuffs is safe for non-ruminant target species. There may be a risk for an increased production of toxic metabolites when unprotected l-tryptophan is used in ruminants. The use of l-tryptophan produced by KCCM 80210 in animal nutrition raises no safety concerns to consumers of animal products and to the environment. The additive under assessment is considered a mild eye irritant. The endotoxin activity of the additive and its dusting potential indicate a risk by inhalation for the users. The additive is not a skin irritant and is not a skin sensitiser. The additive l-tryptophan is regarded as an effective source of the amino acid l-tryptophan for all non-ruminant species. In order to be as efficacious in ruminants as in non-ruminants, it should be protected from ruminal degradation.
应欧盟委员会的要求，动物饲料添加剂及产品或物质专家小组（FEEDAP）被要求就由KCCM 80210发酵生产的L-色氨酸作为营养添加剂用于所有动物种类和类别的饲料时的安全性和有效性发表科学意见。生产菌株KCCM 80210用于生产L-色氨酸是安全的，且在最终产品中未检测到该菌株。专家小组注意到，五批添加剂中有两批不符合申请人提议的干物质基础上98% L-色氨酸的最低规格要求。对于非反刍目标动物物种，使用由KCCM 80210生产的L-色氨酸（≥98%）补充饲料以弥补饲料中L-色氨酸缺乏是安全的。在反刍动物中使用未受保护的L-色氨酸时，可能存在产生有毒代谢物增加的风险。KCCM 80210生产的L-色氨酸用于动物营养对动物产品消费者和环境不存在安全问题。所评估的添加剂被认为是一种轻度眼刺激物。添加剂的内毒素活性及其扬尘潜力表明使用者存在吸入风险。该添加剂不是皮肤刺激物，也不是皮肤致敏剂。添加剂L-色氨酸被认为是所有非反刍动物物种的有效L-色氨酸氨基酸来源。为了在反刍动物中与在非反刍动物中一样有效，应防止其在瘤胃中降解。
